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MeSH Review:

Advanced Cardiac Life Support

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Disease relevance of Advanced Cardiac Life Support

We studied the effect of standard and high doses of epinephrine on coronary perfusion pressure during cardiopulmonary resuscitation in 32 patients whose cardiac arrest was refractory to advanced cardiac life support [1].
After 7.5 minutes of ventricular fibrillation, animals were randomly allocated to two treatment groups: group 1, immediate countershock followed by recommended advanced cardiac life support (ACLS) interventions, or group 2, 0.08 mg/kg epinephrine and manual closed-chest CPR before countershock and ACLS [2].
Hypotension and arrhythmias were treated with epinephrine, open-chest massage, and advanced cardiac life support protocols, respectively [3].
The use of adenosine as a therapeutic and diagnostic tool in wide-complex tachycardia is suggested in the current Advanced Cardiac Life Support (ACLS) guidelines [4].
Inclusion criteria were return of spontaneous circulation within 60 minutes of advanced cardiac life support, hypothermia initiated within 90 minutes, persistent coma, and lack of acute myocardial infarction or unstable dysrhythmia [5].

Psychiatry related information on Advanced Cardiac Life Support

The effect of basic and advanced cardiac life support (BLS and ACLS) on long-term survival is dependent upon both the response time and the quality of intervention [6].

High impact information on Advanced Cardiac Life Support

We randomly assigned 3327 patients to receive up to 15 high doses (5 mg each) or standard doses (1 mg each) of epinephrine according to the current protocol for advanced cardiac life support [7].
INTERVENTIONS--High-dose epinephrine (HDE, 15 mg), high-dose norepinephrine bitartrate (NE, 11 mg), or standard-dose epinephrine (SDE, 1 mg) was blindly substituted for advanced cardiac life support doses of epinephrine [8].
The effectiveness of intravenous amiodarone as short-term treatment also suggests that the drug has an important role in protocols of advanced cardiac life support [9].
Atropine, calcium, calcium-channel blockers, beta-adrenergic-receptor blockers, oxygen, morphine, vasodilators, and potent diuretics are frequently used in advanced cardiac life support (ACLS) [10].
Guidelines for Advanced Cardiac Life Support should not recommend vasopressin in resuscitation protocols until more solid human data on its superiority are available [11].

Chemical compound and disease context of Advanced Cardiac Life Support

PURPOSE: Recent revisions of the advanced cardiac life support guidelines support the use of amiodarone in treating acute cardiac arrhythmia [12].
METHODS: In a porcine model (n=25) of prolonged cardiac arrest, advanced cardiac life support was provided by administration of two or three doses of either vasopressin or epinephrine after 3 or 8 min of basic life support [13].

Associations of Advanced Cardiac Life Support with chemical compounds

MEASUREMENTS AND MAIN RESULTS: Cortisol concentrations were measured before and after advanced cardiac life support and for five consecutive hours after return of spontaneous circulation [14].
The early use of bretylium tosylate is stressed in Advanced Cardiac Life Support protocols because of the agent's antifibrillatory properties, that is, its ability to increase the VF threshold and to block reentry [15].
METHODS: Ten patients undergoing advanced upper endoscopic procedures (endoscopic retrograde cholangiopancreatography, endoscopic ultrasound, esophageal stent placement) received a propofol infusion under the control of a second qualified gastroenterologist with advanced cardiac life support skills [16].
As a prerequisite to the exercise, students successfully complete a 3-week didactic course in Operational and Emergency Medicine which includes Advanced Cardiac Life Support (ACLS) and Advanced Trauma Life Support (ATLS) Provider Courses [17].
Patients in whom standard advanced cardiac life support pharmacotherapy failed were randomized to receive placebo or aminophylline, a nonspecific competitive adenosine receptor antagonist [18].

Gene context of Advanced Cardiac Life Support

The ACLS (advanced cardiac life support) Score was previously developed to predict survival from out-of-hospital cardiac arrest [19].
Vasopressin in advanced cardiac life support [20]?
TOX-ACLS: toxicologic-oriented advanced cardiac life support [21].

References

The effect of standard- and high-dose epinephrine on coronary perfusion pressure during prolonged cardiopulmonary resuscitation. Paradis, N.A., Martin, G.B., Rosenberg, J., Rivers, E.P., Goetting, M.G., Appleton, T.J., Feingold, M., Cryer, P.E., Wortsman, J., Nowak, R.M. JAMA (1991) [Pubmed]
Treatment of prolonged ventricular fibrillation. Immediate countershock versus high-dose epinephrine and CPR preceding countershock. Niemann, J.T., Cairns, C.B., Sharma, J., Lewis, R.J. Circulation (1992) [Pubmed]
Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Groban, L., Deal, D.D., Vernon, J.C., James, R.L., Butterworth, J. Anesth. Analg. (2001) [Pubmed]
Adenosine in wide-complex tachycardia. Herbert, M.E., Votey, S.R. Annals of emergency medicine. (1997) [Pubmed]
Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol. Felberg, R.A., Krieger, D.W., Chuang, R., Persse, D.E., Burgin, W.S., Hickenbottom, S.L., Morgenstern, L.B., Rosales, O., Grotta, J.C. Circulation (2001) [Pubmed]
Can better basic and advanced cardiac life support improve outcome from cardiac arrest? Kaye, W., Mancini, M.E., Rallis, S.F., Linhares, K.C., Angell, M.L., Donovan, D.S., Zajano, N.C., Finger, J.A. Crit. Care Med. (1985) [Pubmed]
A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. European Epinephrine Study Group. Gueugniaud, P.Y., Mols, P., Goldstein, P., Pham, E., Dubien, P.Y., Deweerdt, C., Vergnion, M., Petit, P., Carli, P. N. Engl. J. Med. (1998) [Pubmed]
A randomized clinical trial of high-dose epinephrine and norepinephrine vs standard-dose epinephrine in prehospital cardiac arrest. Callaham, M., Madsen, C.D., Barton, C.W., Saunders, C.E., Pointer, J. JAMA (1992) [Pubmed]
The role of intravenous amiodarone in the management of cardiac arrhythmias. Desai, A.D., Chun, S., Sung, R.J. Ann. Intern. Med. (1997) [Pubmed]
Cardiovascular pharmacology. III: Atropine, calcium, calcium blockers, and beta-blockers. Paraskos, J.A. Circulation (1986) [Pubmed]
Vasopressin for cardiac arrest: a systematic review and meta-analysis. Aung, K., Htay, T. Arch. Intern. Med. (2005) [Pubmed]
Amiodarone administered for cardiac resuscitation does not alter the integrity of noncontrast cerebral computed tomography performed on neurologically symptomatic patients before therapeutic cardiac catheterization. Ptak, T., Novelline, R.A. Journal of computer assisted tomography. (2003) [Pubmed]
Fibrillation power, an alternative method of ECG spectral analysis for prediction of countershock success in a porcine model of ventricular fibrillation. Hamprecht, F.A., Achleitner, U., Krismer, A.C., Lindner, K.H., Wenzel, V., Strohmenger, H.U., Thiel, W., van Gunsteren, W.F., Amann, A. Resuscitation. (2001) [Pubmed]
A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest. Schultz, C.H., Rivers, E.P., Feldkamp, C.S., Goad, E.G., Smithline, H.A., Martin, G.B., Fath, J.J., Wortsman, J., Nowak, R.M. Crit. Care Med. (1993) [Pubmed]
Management of ventricular dysrhythmias in the prehospital and emergency department setting. Mayer, N.M. Am. J. Cardiol. (1984) [Pubmed]
Gastroenterologist-administered propofol for therapeutic upper endoscopy with graphic assessment of respiratory activity: a case series. Vargo, J.J., Zuccaro, G., Dumot, J.A., Shay, S.S., Conwell, D.L., Morrow, J.B. Gastrointest. Endosc. (2000) [Pubmed]
Medical simulation for disaster casualty management training. Cowan, M.L., Cloutier, M.G. The Journal of trauma. (1988) [Pubmed]
Adenosine receptor antagonism in refractory asystolic cardiac arrest: results of a human pilot study. Mader, T.J., Gibson, P. Resuscitation. (1997) [Pubmed]
Is the ACLS score a valid prediction rule for survival after cardiac arrest? Haukoos, J.S., Lewis, R.J., Stratton, S.J., Niemann, J.T. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (2003) [Pubmed]
Vasopressin in advanced cardiac life support? Cain, B.S., Shannon-Cain, J. Crit. Care Med. (2001) [Pubmed]
TOX-ACLS: toxicologic-oriented advanced cardiac life support. Albertson, T.E., Dawson, A., de Latorre, F., Hoffman, R.S., Hollander, J.E., Jaeger, A., Kerns, W.R., Martin, T.G., Ross, M.P. Annals of emergency medicine. (2001) [Pubmed]

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