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Gene Review:

mcl1a - myeloid cell leukemia 1a

Danio rerio

Synonyms: SO:0000704, fb72f02, wu:fb70a08, wu:fb72f02, zfMLP1, ...

Her, G.M. et al., Chen, M.C. et al.

Her, Cheng, Hong, Sundaram, Wu,

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Disease relevance of mcl1a

Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a [1].

High impact information on mcl1a

Increased cell death and proliferation was found in both hepatic cells of zebrafish larvae overexpressing either zfBLP1 or zfMcl-1a [1].
(This finding may have been due to liver abnormalities that led to failure of liver function.) In conclusion, transgenic overexpression of zfBLP1 or zfMcl-1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia [1].
Of interest, the expression of cyclin genes (A2, B, D1, and E), hepatocyte nuclear factor genes (HNF-1alpha, beta, -3beta, and 4alpha), and oncogenic markers (P53, c-myc, beta-catenin, N-ras, and gankyrin) were up-regulated, while the expression of C/EBP-alpha was down-regulated in a zfMcl-1a-mediated anti-apoptotic process of the liver [1].
Northern blot analysis indicated that zfMcl-1a mRNA is 1.5 kb and was expressed in oocytes and throughout embryonic development [2].

Biological context of mcl1a

To evaluate the effect of dysregulated hepatocyte apoptosis during zebrafish hepatogenesis, we demonstrate the transgenic overexpression of either zfBLP1 or zfMcl-1a in zebrafish larval liver [1].

Other interactions of mcl1a

In previous studies, we identified two novel proteins, zfBLP1 and zfMcl-1a, which are similar to those of the Bcl-2 family as a group of evolutionarily conserved proteins that regulate cellular anti-apoptosis [1].

References

Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a. Her, G.M., Cheng, C.H., Hong, J.R., Sundaram, G.S., Wu, J.L. Dev. Dyn. (2006) [Pubmed]
Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Chen, M.C., Gong, H.Y., Cheng, C.Y., Wang, J.P., Hong, J.R., Wu, J.L. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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