Gene Review:
Mcl1 - myeloid cell leukemia sequence 1
Mus musculus
Synonyms:
AW556805, Bcl-2-related protein EAT/mcl1, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Mcl-1
- Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells. Okita, H., Umezawa, A., Suzuki, A., Hata, J. Biochim. Biophys. Acta (1998)
- The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. van Delft, M.F., Wei, A.H., Mason, K.D., Vandenberg, C.J., Chen, L., Czabotar, P.E., Willis, S.N., Scott, C.L., Day, C.L., Cory, S., Adams, J.M., Roberts, A.W., Huang, D.C. Cancer Cell (2006)
- Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Baskin-Bey, E.S., Huang, W., Ishimura, N., Isomoto, H., Bronk, S.F., Braley, K., Craig, R.W., Moore, D.D., Gores, G.J. Hepatology (2006)
- Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas. Austin, M., Cook, S.J. J. Biol. Chem. (2005)
- Hypoxia selects for high-metastatic Lewis lung carcinoma cells overexpressing Mcl-1 and exhibiting reduced apoptotic potential in solid tumors. Koshikawa, N., Maejima, C., Miyazaki, K., Nakagawara, A., Takenaga, K. Oncogene (2006)
- Mcl-1 deficiency results in peri-implantation embryonic lethality. Rinkenberger, J.L., Horning, S., Klocke, B., Roth, K., Korsmeyer, S.J. Genes Dev. (2000)
- Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Chen, L., Willis, S.N., Wei, A., Smith, B.J., Fletcher, J.I., Hinds, M.G., Colman, P.M., Day, C.L., Adams, J.M., Huang, D.C. Mol. Cell (2005)
- BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Kuwana, T., Bouchier-Hayes, L., Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R., Newmeyer, D.D. Mol. Cell (2005)
- BCMA is essential for the survival of long-lived bone marrow plasma cells. O'Connor, B.P., Raman, V.S., Erickson, L.D., Cook, W.J., Weaver, L.K., Ahonen, C., Lin, L.L., Mantchev, G.T., Bram, R.J., Noelle, R.J. J. Exp. Med. (2004)
- Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance. Marriott, H.M., Bingle, C.D., Read, R.C., Braley, K.E., Kroemer, G., Hellewell, P.G., Craig, R.W., Whyte, M.K., Dockrell, D.H. J. Clin. Invest. (2005)
- Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide. Thallinger, C., Wolschek, M.F., Maierhofer, H., Skvara, H., Pehamberger, H., Monia, B.P., Jansen, B., Wacheck, V., Selzer, E. Clin. Cancer Res. (2004)
- Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. MacCallum, D.E., Melville, J., Frame, S., Watt, K., Anderson, S., Gianella-Borradori, A., Lane, D.P., Green, S.R. Cancer Res. (2005)
- Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1. Ma, Y., Cress, W.D., Haura, E.B. Mol. Cancer Ther. (2003)
- Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Mori, M., Burgess, D.L., Gefrides, L.A., Foreman, P.J., Opferman, J.T., Korsmeyer, S.J., Cavalheiro, E.A., Naffah-Mazzacoratti, M.G., Noebels, J.L. Cell Death Differ. (2004)
- Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. Day, C.L., Chen, L., Richardson, S.J., Harrison, P.J., Huang, D.C., Hinds, M.G. J. Biol. Chem. (2005)
- Expression of Mcl-1 in cerebellar granule neurons is regulated by IGF-I in a developmentally specific fashion. Zhang, J., D'Ercole, A.J. Brain Res. Dev. Brain Res. (2004)
- Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Opferman, J.T., Letai, A., Beard, C., Sorcinelli, M.D., Ong, C.C., Korsmeyer, S.J. Nature (2003)
- Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Chen, S., Dai, Y., Harada, H., Dent, P., Grant, S. Cancer Res. (2007)
- Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells. Moulding, D.A., Giles, R.V., Spiller, D.G., White, M.R., Tidd, D.M., Edwards, S.W. Blood (2000)
- Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. Michels, J., O'Neill, J.W., Dallman, C.L., Mouzakiti, A., Habens, F., Brimmell, M., Zhang, K.Y., Craig, R.W., Marcusson, E.G., Johnson, P.W., Packham, G. Oncogene (2004)
- Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Ikezoe, T., Yang, Y., Bandobashi, K., Saito, T., Takemoto, S., Machida, H., Togitani, K., Koeffler, H.P., Taguchi, H. Mol. Cancer Ther. (2005)
- Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway. Henson, E.S., Gibson, E.M., Villanueva, J., Bristow, N.A., Haney, N., Gibson, S.B. J. Cell. Biochem. (2003)
- Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. Meng, F., Yamagiwa, Y., Ueno, Y., Patel, T. J. Hepatol. (2006)
- Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh, T., Itoh, A., Pleasure, D. J. Neurochem. (2003)
- Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model. Sander, S., Bullinger, L., Karlsson, A., Giuriato, S., Hernandez-Boussard, T., Felsher, D.W., Pollack, J.R. Oncogene (2005)