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Gene Review

RAB5C  -  RAB5C, member RAS oncogene family

Homo sapiens

Synonyms: L1880, RAB5CL, RAB5L, RABL, Ras-related protein Rab-5C
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High impact information on RAB5C

  • Labeling with probes to telomeres and centromeres confirmed a striking Rabl configuration in all cells, with a clear clustering of the centromeres, and cell files often maintained a common polarity through several division cycles [1].
  • After germinating seeds either in the presence of 5-Azacytidine (5-AC), which leads to DNA hypomethylation, or trichostatin A (TSA), which results in histone hyperacetylation, the architecture of the interphase chromosome arms changes significantly even though the overall Rabl configuration is maintained [2].
  • Simultaneous FISH with pSc200 subtelomeric tandem repeat and CCS1 centromeric sequence revealed that at pre-meiotic interphase the two domains are in a bipolar Rabl orientation in both the PMCs and tapetal cells [3].
  • The polar arrangement of telomeres in interphase and meiosis. Rabl organization and the bouquet [4].
  • This association pattern, also exhibited by two similar MCs in human beings, the minute Y of a marsupial and certain B chromosomes in plants, probably reflects the Rabl orientation of chromosomes in interphase [5].

Biological context of RAB5C


Anatomical context of RAB5C


Analytical, diagnostic and therapeutic context of RAB5C

  • The mitotic chromosomes showed neither primary constriction nor Rabl orientation whereas the meiotic ones exhibited the typical quadripartite structure characteristic of holocentrics, supporting the assumption of holocentric chromosomes as a synapomorphy of Cuscuta subg [10].


  1. Transcription sites are not correlated with chromosome territories in wheat nuclei. Abranches, R., Beven, A.F., Aragón-Alcaide, L., Shaw, P.J. J. Cell Biol. (1998) [Pubmed]
  2. The architecture of interphase chromosomes and gene positioning are altered by changes in DNA methylation and histone acetylation. Santos, A.P., Abranches, R., Stoger, E., Beven, A., Viegas, W., Shaw, P.J. J. Cell. Sci. (2002) [Pubmed]
  3. Nuclear dispositions of subtelomeric and pericentromeric chromosomal domains during meiosis in asynaptic mutants of rye (Secale cereale L.). Mikhailova, E.I., Sosnikhina, S.P., Kirillova, G.A., Tikholiz, O.A., Smirnov, V.G., Jones, R.N., Jenkins, G. J. Cell. Sci. (2001) [Pubmed]
  4. The polar arrangement of telomeres in interphase and meiosis. Rabl organization and the bouquet. Cowan, C.R., Carlton, P.M., Cande, W.Z. Plant Physiol. (2001) [Pubmed]
  5. Centromeric association of a microchromosome in a Turner syndrome patient with a pseudodicentric Y. Rivera, H., Domínguez, M.G., Vásquez, A.I., Ramos, A.L., Fragoso, R. Hum. Genet. (1993) [Pubmed]
  6. Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene. Han, H.J., Sudo, K., Inazawa, J., Nakamura, Y. Cytogenet. Cell Genet. (1996) [Pubmed]
  7. Chromosome arrangement and behaviour of two rye homologous telosomes at the onset of meiosis in disomic wheat-5RL addition lines with and without the Ph1 locus. Maestra, B., Hans de Jong, J., Shepherd, K., Naranjo, T. Chromosome Res. (2002) [Pubmed]
  8. Interphase chromosomes and the Rabl configuration: does genome size matter? Santos, A.P., Shaw, P. Journal of microscopy. (2004) [Pubmed]
  9. Non-Rabl patterns of centromere and telomere distribution in the interphase nuclei of plant cells. Dong, F., Jiang, J. Chromosome Res. (1998) [Pubmed]
  10. Heterochromatin and rDNA sites distribution in the holocentric chromosomes of Cuscuta approximata Bab. (Convolvulaceae). Guerra, M., García, M.A. Genome (2004) [Pubmed]
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