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Gene Review

RLF  -  rearranged L-myc fusion

Homo sapiens

Synonyms: Rearranged L-myc fusion gene protein, ZN-15L, ZNF292L, Zinc finger protein Rlf, Zn-15-related protein, ...
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Disease relevance of RLF

  • Fifty-nine cases of RLF were detected in a total of approximately 175 examinations for the birth weight category under 1700 gm during a five-year period [1].
  • The development of RLF was associated with prolonged oxygen exposure and the presence of bacterial sepsis [2].
  • Since examinations performed during the fourth fortnight of life were 85% positive for RLF, and since retinal detachment in this condition rarely occurs before age 8 weeks, the present series of cases suggests that the optimal time for a single screening examination for RLF is between 7 and 9 weeks of age [1].
  • In contrast, of the 13 surviving infants in group II (survival 76%), nine were ventilated (median = 8 days), six had moderate to severe bronchopulmonary dysplasia, and six had mild RLF [3].
  • This condition is sometimes confused with retrolental fibroplasia, and FEV is probably a more frequently occurring disease than previously thought, because of confusion with RLF [4].

High impact information on RLF


Biological context of RLF

  • The zinc fingers are not contained in the 79 amino acid N-terminal region of RLF involved in the RLF-L-myc fusions, and the transforming ability of the RLF-L-myc and the normal L-myc proteins is indistinguishable [5].

Analytical, diagnostic and therapeutic context of RLF

  • The effect of blood transfusion on the occurrence of RLF was evaluated in 58 infants who weighed less than 1001 g at birth (Group I) and 70 oxygen treated infants of various birth weights (Group II) [9].


  1. Optimal timing of examination for acute retrolental fibroplasia. Palmer, E.A. Ophthalmology (1981) [Pubmed]
  2. Outcome for survivors of mechanical ventilation weighing less than 1,250 gm at birth. Rothberg, A.D., Maisels, M.J., Bagnato, S., Murphy, J., Gifford, K., McKinley, K., Palmer, E.A., Vannucci, R.C. J. Pediatr. (1981) [Pubmed]
  3. Preterm birth at 23 to 26 weeks' gestation: is active obstetric management justified? Nwaesei, C.G., Young, D.C., Byrne, J.M., Vincer, M.J., Sampson, D., Evans, J.R., Allen, A.C., Stinson, D.A. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  4. Familial exudative vitreoretinopathy. Bergen, R.L., Glassman, R. Annals of ophthalmology. (1983) [Pubmed]
  5. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. Mäkelä, T.P., Hellsten, E., Vesa, J., Hirvonen, H., Palotie, A., Peltonen, L., Alitalo, K. Oncogene (1995) [Pubmed]
  6. The recrudescent epidemic of retrolental fibroplasia. Robin, E.D., Burke, C.M. Chest (1986) [Pubmed]
  7. Lateralization of the frontal lobe functions elicited by a cognitive bias task is a fundamental process. Lesion study. Aoyagi, K., Aihara, M., Goldberg, E., Nakazawa, S. Brain Dev. (2005) [Pubmed]
  8. Acute proliferative retrolental fibroplasia: evolution of the lesion. Flynn, J.T. Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology. (1975) [Pubmed]
  9. Blood transfusion: a possible risk factor in retrolental fibroplasia. Clark, C., Gibbs, J.A., Maniello, R., Outerbridge, E.W., Aranda, J.V. Acta paediatrica Scandinavica. (1981) [Pubmed]
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