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Gene Review

NBEAP1  -  neurobeachin pseudogene 1

Homo sapiens

Synonyms: BCL8, BCL8A, Neurobeachin pseudogene 1
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Disease relevance of BCL8

  • BCL8 is a novel human gene family initially identified through cloning of BCL8A, located at the t(14;15)(q32;q11-q13) translocation breakpoint, in a case of diffuse large B-cell lymphoma [1].
  • BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma [2].

High impact information on BCL8

  • By reverse transcription-PCR analysis of RNA extracted from frozen DLCL samples and lymphoma cell lines, BCL8 expression was detected in all patients carrying 15q11-13 abnormalities and in a fraction of randomly selected DLCL patients [2].
  • Analysis of the BCL8 cDNA clones isolated from human testis cDNA library showed that the BCL8 gene generates a major transcript of 2.6 kb and a less prominent 4.5-kb species due to differential polyadenylylation [2].
  • Ectopic expression of BCL8 in a significant proportion of DLCL suggests an important role for this gene in the molecular pathogenesis of B cell lymphoma [2].
  • To identify the putative gene, here named BCL8, involved in these translocations we have cloned the breakpoint region from a DLCL patient with t(14;15)(q32;q11-13) and the corresponding germ-line region from chromosome 15 [2].
  • These results suggest that the BCL8 gene is not normally expressed in lymphoid tissues, but its expression can be activated by chromosomal translocation or by other mechanisms in DLCL [2].

Biological context of BCL8

  • The phylogenetically conserved BCL8 gene family evolved by transchromosomal and intrachromosomal duplications within the human genome [1].

Anatomical context of BCL8


Other interactions of BCL8

  • LRBA, a human gene with a ubiquitous expression pattern mapping to 4q32, encodes a protein closely related to BCL8 [1].


  1. BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function. Dyomin, V.G., Chaganti, S.R., Dyomina, K., Palanisamy, N., Murty, V.V., Dalla-Favera, R., Chaganti, R.S. Genomics (2002) [Pubmed]
  2. BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma. Dyomin, V.G., Rao, P.H., Dalla-Favera, R., Chaganti, R.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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