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Gene Review

sox10  -  SRY (sex determining region Y)-box 10

Danio rerio

Synonyms: SO:0000704, cls/sox10, zgc:100757
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Disease relevance of sox10


High impact information on sox10

  • sox10 is necessary for development of neural and pigment cell derivatives of the neural crest (NC) [2].
  • Consistent with this, we have isolated a novel sox10 mutant that lacks glia and yet displays a neurogenic DRG phenotype [2].
  • We proposed that sox10 functioned in specification of sensory neurons, whereas others suggested that sensory neuronal defects were merely secondary to absence of glia [2].
  • We demonstrate that decrement of the function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells [3].
  • We demonstrate that the zebrafish mitfa promoter has sox10 binding sites necessary for activity in vitro, consistent with studies using mammalian cell cultures that have shown that Sox10 directly regulates Mitf expression [4].

Anatomical context of sox10


Associations of sox10 with chemical compounds


Other interactions of sox10

  • We further demonstrate that, during pigment pattern metamorphosis, puma mutants have deficiencies in the numbers of cells expressing transcripts for kit, ednrb1, and fms, as well as the HMG domain transcription factor sox10 [7].


  1. Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Elworthy, S., Pinto, J.P., Pettifer, A., Cancela, M.L., Kelsh, R.N. Mech. Dev. (2005) [Pubmed]
  2. A direct role for Sox10 in specification of neural crest-derived sensory neurons. Carney, T.J., Dutton, K.A., Greenhill, E., Delfino-Mach??n, M., Dufourcq, P., Blader, P., Kelsh, R.N. Development (2006) [Pubmed]
  3. A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio. Whitlock, K.E., Smith, K.M., Kim, H., Harden, M.V. Development (2005) [Pubmed]
  4. Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development. Elworthy, S., Lister, J.A., Carney, T.J., Raible, D.W., Kelsh, R.N. Development (2003) [Pubmed]
  5. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Montero-Balaguer, M., Lang, M.R., Sachdev, S.W., Knappmeyer, C., Stewart, R.A., De La Guardia, A., Hatzopoulos, A.K., Knapik, E.W. Dev. Dyn. (2006) [Pubmed]
  6. Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Barrallo-Gimeno, A., Holzschuh, J., Driever, W., Knapik, E.W. Development (2004) [Pubmed]
  7. Essential role for puma in development of postembryonic neural crest-derived cell lineages in zebrafish. Parichy, D.M., Turner, J.M., Parker, N.B. Dev. Biol. (2003) [Pubmed]
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