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Gene Review

P3H1  -  prolyl 3-hydroxylase 1

Homo sapiens

Synonyms: GROS1, Growth suppressor 1, LEPRE1, LEPRECAN, Leprecan-1, ...
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Disease relevance of LEPRE1

  • Mycobacterium lepre was demonstrable in testicular aspirates from all patients with multibacillary and in three with paucibacillary leprosy [1].
  • 2. Four human liver cancer cell lines, namely HepG2, Hep3B, SK-Hep1 and PLC/PRF/5, and four leukaemia cell lines, namely K562, U937, P3H1 and Raji, were used in the present study [2].
  • The still increasing amount of carriers and anemics by thalassemia (Th) and other Hb-pathies (approximately 4,000 among approximately 48,000 investigated people) have shown that Campania is the most affected world area by all Hb Lepre conditions [3].

Psychiatry related information on LEPRE1

  • Community action research among the Assiniboine and Gros Ventre tribes of the Fort Belknap Indian reservation in Montana was undertaken to identify the cultural grounds for innovative mental health service delivery [4].

High impact information on LEPRE1

  • Immunohistochemistry with a monoclonal antibody specific for chick P3H1 localizes P3H1 specifically to tissues that express fibrillar collagens, suggesting that other P3H family members may be responsible for modifying basement membrane collagens [5].
  • The primary structure of the enzyme, which we now call P3H1, demonstrates that P3H1 is a member of a family of prolyl 3-hydroxylases, which share the conserved residues present in the active site of prolyl 4-hydroxylase and lysyl hydroxylase [5].
  • While our data implied that Gros1 is a novel growth suppressor gene on human chromosome 1, an independent study has recently characterized its rat-homolog as a leucine proline-enriched novel basement membrane-associated proteoglycan leprecan [6].
  • By immunoscreening with an antibody raised against a plasma membrane protein, we have cloned a growth suppressor gene, Gros1 and assigned it to short arm of human chromosome 1 [6].
  • Based on studies of other ecosystems, we hypothesized that alien plants will be restricted to disturbed areas near human activity and will not be found in natural areas of boreal ecosystems in Gros Morne National Park (Canada), a protected area experiencing a wide range of disturbance regimes [7].

Biological context of LEPRE1

  • The IC50 values for C. chinensis on K562, U937 and P3H1 cell lines were 29, 29 and 31 microg/mL, respectively [2].


  1. Cytology of testicular changes in leprosy. Singh, N., Arora, V.K., Jain, A., Bhattacharya, S.N., Bhatia, A. Acta Cytol. (2002) [Pubmed]
  2. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Lin, C.C., Ng, L.T., Hsu, F.F., Shieh, D.E., Chiang, L.C. Clin. Exp. Pharmacol. Physiol. (2004) [Pubmed]
  3. Hb Lepore and (haemo-) blastomata. Quattrin, N., Mastrobouni, A., Laudisio, F.L., Brancaccio, V., Pagnini, D. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1976) [Pubmed]
  4. Research reservations: response and responsibility in an American Indian community. Gone, J.P. American journal of community psychology. (2006) [Pubmed]
  5. Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes. Vranka, J.A., Sakai, L.Y., Bächinger, H.P. J. Biol. Chem. (2004) [Pubmed]
  6. Gros1, a potential growth suppressor on chromosome 1: its identity to basement membrane-associated proteoglycan, leprecan. Kaul, S.C., Sugihara, T., Yoshida, A., Nomura, H., Wadhwa, R. Oncogene (2000) [Pubmed]
  7. Are boreal ecosystems susceptible to alien plant invasion? Evidence from protected areas. Rose, M., Hermanutz, L. Oecologia (2004) [Pubmed]
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