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Gene Review

MLST8  -  MTOR associated protein, LST8 homolog (S....

Homo sapiens

Synonyms: G protein beta subunit-like, GBL, Gable, GbetaL, LST8, ...
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Disease relevance of GBL

  • Our findings showed that serum levels of IL-2 and sIL-2R were increased in all cancer patients; on the contrary, sICAM-1 serum levels were not significantly increased in GBL and astrocytoma patients [1].
  • Ninety-nine patients bearing recurrent malignant glioma sequentially selected according to strict eligibility criteria (72 GBL and 27 AA) entered the study [2].
  • 14 cases of astrocytomas (WHO grade II, III), 20 cases of glioblastomas (GBL, WHO grade IV), 5 cases of lung carcinoma and 6 cases of kidney carcinoma were studied; the results were compared with 15 healthy controls [1].
  • EDs and poison control centers nationwide will undoubtedly continue to manage GHB, GBL, and 1,4-BD toxicities [3].

High impact information on GBL


Biological context of GBL

  • These studies show that hydrolysis of GBL to GHB does occur in aqueous-based solutions, with samples and time frames that are relevant to forensic testing [8].

Analytical, diagnostic and therapeutic context of GBL

  • Non-viable eggs of Morelet's crocodile (Crocodylus moreletii) were collected from Gold Button (GBL) and New River lagoons (NRL) in northern Belize and screened for organochlorine (OC) compounds using gas chromatography (GC) with electron capture detection (ECD) [5].
  • Heat increased and refrigeration decreased the rate of GBL hydrolysis relative to ambient conditions [8].
  • GHB and GBL contents were determined using high performance liquid chromatography (HPLC) [8].


  1. Evaluation of serum levels of cytokines and intercellular adhesion molecule-1 (ICAM-1) in astrocytic tumours. Nano, R., Capelli, E., Argentina, F., Facoetti, A., Gerzeli, G. Cell. Mol. Biol. (Noisy-le-grand) (2003) [Pubmed]
  2. Efficacy of intratumoral delivery of mitoxantrone in recurrent malignant glial tumours. Boiardi, A., Eoli, M., Salmaggi, A., Zappacosta, B., Fariselli, L., Milanesi, I., Broggi, G., Silvani, A. J. Neurooncol. (2001) [Pubmed]
  3. Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature. Shannon, M., Quang, L.S. Pediatric emergency care. (2000) [Pubmed]
  4. Drug use and sexual risk behavior among gay and bisexual men who attend circuit parties: a venue-based comparison. Colfax, G.N., Mansergh, G., Guzman, R., Vittinghoff, E., Marks, G., Rader, M., Buchbinder, S. J. Acquir. Immune Defic. Syndr. (2001) [Pubmed]
  5. Organochlorine contaminants in Morelet's crocodile (Crocodylus moreletii) eggs from Belize. Wu, T.H., Rainwater, T.R., Platt, S.G., McMurry, S.T., Anderson, T.A. Chemosphere (2000) [Pubmed]
  6. 1H NMR analysis of GHB and GBL: further findings on the interconversion and a preliminary report on the analysis of GHB in serum and urine. Del Signore, A.G., McGregor, M., Cho, B.P. J. Forensic Sci. (2005) [Pubmed]
  7. GL-701 Genelabs. Norman, P. Current opinion in investigational drugs (London, England : 2000) (2001) [Pubmed]
  8. The chemical interconversion of GHB and GBL: forensic issues and implications. Ciolino, L.A., Mesmer, M.Z., Satzger, R.D., Machal, A.C., McCauley, H.A., Mohrhaus, A.S. J. Forensic Sci. (2001) [Pubmed]
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