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Gene Review

LMBR1  -  limb development membrane protein 1

Homo sapiens

Synonyms: ACHP, C7orf2, DIF14, Differentiation-related gene 14 protein, FLJ11665, ...
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Disease relevance of LMBR1

  • ACHP was also found to suppress HIV-1 long terminal repeat (LTR)-driven gene expression through the inhibition of NF-kappaB activation [1].
  • These findings suggest that ACHP acts as a potent suppressor of TNF-alpha-induced HIV replication in latently infected cells and that this inhibition is mediated through suppression of IKK activity [1].

High impact information on LMBR1

  • We then examined the effect of a novel IkappaB kinase inhibitor, 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-yl nicotinonitrile (ACHP) [2].
  • In addition, we observed the treatment of ACHP augmented the cytotoxic effects of vincristine and melphalan (l-phenylalanine mustard), conventional antimyeloma drugs [2].
  • When Tax-active and Tax-inactive cell lines were compared, ACHP could preferentially inhibit cell growth of Tax-active cells [3].
  • These findings indicate that ACHP and its derivatives are effective in inducing ATL cell death and thus feasible candidates for the treatment of ATL [3].
  • We found that ACHP could inhibit the phosphorylation of IkappaBalpha and p65, as well as NF-kappaB DNA-binding, associated with downregulation of the NF-kappaB target genes and induce cell growth arrest and apoptosis in these cells [3].

Other interactions of LMBR1

  • A recently proposed candidate gene for 7q36 linked preaxial polydactyly is LMBR1, encoding a novel transmembrane receptor which may be an upstream regulator of SHH [4].

Analytical, diagnostic and therapeutic context of LMBR1


  1. Inhibition of human immunodeficiency virus type 1 replication in latently infected cells by a novel IkappaB kinase inhibitor. Victoriano, A.F., Asamitsu, K., Hibi, Y., Imai, K., Barzaga, N.G., Okamoto, T. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. Growth inhibition of multiple myeloma cells by a novel IkappaB kinase inhibitor. Sanda, T., Iida, S., Ogura, H., Asamitsu, K., Murata, T., Bacon, K.B., Ueda, R., Okamoto, T. Clin. Cancer Res. (2005) [Pubmed]
  3. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Sanda, T., Asamitsu, K., Ogura, H., Iida, S., Utsunomiya, A., Ueda, R., Okamoto, T. Leukemia (2006) [Pubmed]
  4. A novel acropectoral syndrome maps to chromosome 7q36. Dundar, M., Gordon, T.M., Ozyazgan, I., Oguzkaya, F., Ozkul, Y., Cooke, A., Wilkinson, A.G., Holloway, S., Goodman, F.R., Tolmie, J.L. J. Med. Genet. (2001) [Pubmed]
  5. Two novel point mutations in the long-range SHH enhancer in three families with triphalangeal thumb and preaxial polydactyly. Gurnett, C.A., Bowcock, A.M., Dietz, F.R., Morcuende, J.A., Murray, J.C., Dobbs, M.B. Am. J. Med. Genet. A (2007) [Pubmed]
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