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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MPPE1  -  metallophosphoesterase 1

Homo sapiens

Synonyms: Metallophosphoesterase 1, PGAP5, PP579, Post-GPI attachment to proteins factor 5
 
 
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Disease relevance of MPPE1

  • The MPPE was significantly greater in the normal group than in the rejection or infarction group (P < .05) [1].
  • INTRODUCTION: N-Methyl,N-propargyphenylethylamine (MPPE) is a novel analog of (-)-deprenyl, a drug prescribed for Parkinson's disease and shown to have neuroprotective and neurorescue properties in a wide variety of in vitro and in vivo models [2].
  • PURPOSE: To clarify the pathophysiology of multifocal posterior pigment epitheliopathy (MPPE), or bullous retinal detachment (RD)-an unusual manifestation of central serous chorioretinopathy (CSC)-we evaluated indocyanine green (ICG) angiographic findings of patients with MPPE [3].
 

High impact information on MPPE1

  • Mutation of an asparagine residue in the GNHD motif that is conserved throughout the metallophosphoesterase enzymes almost completely abolished catalytic activity, and these studies therefore represent the first mutational analysis of this class of phosphodiesterases [4].
  • 3' RACE analysis defined a single functional polyadenylation site within the 3' UTR of the GNAL gene, while RT-PCR analysis revealed an alternatively spliced form of MPPE1, which included an additional exon located within the last intron [5].
  • cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2 [5].
  • The genomic organization of the human MPPE1 gene proved to consist of 14 exons and to span about 27 kb [5].
  • METHOD: In this paper, extractive derivatization with pentafluorobenzenesulfonyl chloride (PFBSC) followed by electron-capture gas chromatography was utilized to study the metabolism of MPPE [2].
 

Anatomical context of MPPE1

  • In MPPE, a severe form of CSC, the retinal pigment epithelium is involved extensively and widely, and prognosis is unfavorable [3].
  • Imaging techniques included axial and sagittal chemical fat-suppressed T1-weighted image (T1WI) and T2-weighted image (T2WI), additional contrast axial or saggital chemical fat-suppressed T1WI were obtained after 3D contrast MRA for calculating the mean percentage of the parenchymal enhancement (MPPE) of the pancreas and kidney [6].
  • Using this procedure, it has now been shown that beta-phenylethylamine (PEA), N-methylphenylethylamine (N-methylPEA) and N-propargylphenylethylamine (N-propargylPEA) are formed from MPPE during incubation of this drug with human liver microsomes [2].
 

Associations of MPPE1 with chemical compounds

  • MPPE is also neuroprotective, but has the advantage over (-)-deprenyl of not being metabolized to amphetamine or N-methylamphetamine [2].

References

  1. Acute pancreatic transplant rejection: evaluation with dynamic contrast-enhanced MR imaging compared with histopathologic analysis. Krebs, T.L., Daly, B., Wong-You-Cheong, J.J., Carroll, K., Bartlett, S.T. Radiology. (1999) [Pubmed]
  2. A rapid, sensitive electron-capture gas chromatographic procedure for analysis of metabolites of N-methyl,N-propargylphenylethylamine, a potential neuroprotective agent. Rittenbach, K., Sloley, B.D., Ling, L., Coutts, R.T., Shan, J., Baker, G.B. Journal of pharmacological and toxicological methods. (2005) [Pubmed]
  3. Indocyanine green angiography and pathophysiology of multifocal posterior pigment epitheliopathy. Uyama, M., Matsunaga, H., Matsubara, T., Fukushima, I., Takahashi, K., Nishimura, T. Retina (Philadelphia, Pa.) (1999) [Pubmed]
  4. The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. Shenoy, A.R., Sreenath, N., Podobnik, M., Kovacevic, M., Visweswariah, S.S. Biochemistry (2005) [Pubmed]
  5. cDNA cloning, genomic organization and expression of the novel human metallophosphoesterase gene MPPE1 on chromosome 18p11.2. Vuoristo, J.T., Ala-Kokko, L. Cytogenet. Cell Genet. (2001) [Pubmed]
  6. MRI and magnetic resonance angiography in evaluating simultaneous pancreas-kidney transplantation. Zhu, W., Xia, L., Qi, J., Wang, C., Hu, D., Hu, J., Feng, D. Chin. Med. J. (2002) [Pubmed]
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