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Gene Review

Abhd5  -  abhydrolase domain containing 5

Mus musculus

Synonyms: 1-acylglycerol-3-phosphate O-acyltransferase ABHD5, 1300003D03Rik, 2010002J10Rik, Abhydrolase domain-containing protein 5, CDS, ...
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High impact information on Abhd5


Biological context of Abhd5

  • This interaction seems physiologically important because CGI-58 mutants carrying an amino acid substitution identical to that found in CDS lost the ability to be recruited to LDs [3].

Anatomical context of Abhd5

  • We have used proteomic analysis to identify CGI-58, a member of the alpha/beta-hydrolase fold family of enzymes, as a component of lipid droplets of 3T3-L1 adipocytes [2].
  • Endogenous CGI-58 was distributed predominantly on the surface of LDs in differentiated 3T3-L1 cells, and its expression increased during adipocyte differentiation [3].
  • CGI-58 mRNA is highly expressed in adipose tissue and testes, tissues that also express perilipins, and at lower levels in liver, skin, kidney, and heart [2].

Physical interactions of Abhd5


Other interactions of Abhd5


  1. Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism. Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacobsen, P., Tornqvist, H., Zechner, R., Zimmermann, R. J. Biol. Chem. (2006) [Pubmed]
  2. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. Subramanian, V., Rothenberg, A., Gomez, C., Cohen, A.W., Garcia, A., Bhattacharyya, S., Shapiro, L., Dolios, G., Wang, R., Lisanti, M.P., Brasaemle, D.L. J. Biol. Chem. (2004) [Pubmed]
  3. CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. Yamaguchi, T., Omatsu, N., Matsushita, S., Osumi, T. J. Biol. Chem. (2004) [Pubmed]
  4. Analysis of interaction partners for perilipin and ADRP on lipid droplets. Yamaguchi, T., Omatsu, N., Omukae, A., Osumi, T. Mol. Cell. Biochem. (2006) [Pubmed]
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