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Gene Review

Plin1  -  perilipin 1

Mus musculus

Synonyms: 6030432J05Rik, Lipid droplet-associated protein, Peri, Perilipin A, Perilipin-1, ...
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Disease relevance of Plin

  • Breeding the Plin -/- alleles into Leprdb/db mice reverses the obesity by ncreasing the metabolic rate of the mice [1].
  • Plin -/- mice consume more food than control mice, but have normal body weight [1].
  • A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre-, peri- and post-initiational stages of papillomagenesis as compared to the control group [2].
  • Expression of VEGF-D in beta cells of single-transgenic Rip1VEGF-D mice resulted in the formation of peri-insular lymphatic lacunae, often containing leukocyte accumulations and blood hemorrhages [3].
  • Peutz-Jeghers syndrome (PJS, OMIM 175200) is an unusual inherited intestinal polyposis syndrome associated with distinct peri-oral blue/black freckling [1-9] [4].

High impact information on Plin


Chemical compound and disease context of Plin


Biological context of Plin


Anatomical context of Plin


Associations of Plin with chemical compounds


Physical interactions of Plin


Regulatory relationships of Plin


Other interactions of Plin


Analytical, diagnostic and therapeutic context of Plin


  1. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Martinez-Botas, J., Anderson, J.B., Tessier, D., Lapillonne, A., Chang, B.H., Quast, M.J., Gorenstein, D., Chen, K.H., Chan, L. Nat. Genet. (2000) [Pubmed]
  2. Evaluation of chemopreventive action of Ginsenoside Rp1. Kumar, A., Kumar, M., Panwar, M., Samarth, R.M., Park, T.Y., Park, M.H., Kimura, H. Biofactors (2006) [Pubmed]
  3. Distinct roles of vascular endothelial growth factor-d in lymphangiogenesis and metastasis. Kopfstein, L., Veikkola, T., Djonov, V.G., Baeriswyl, V., Schomber, T., Strittmatter, K., Stacker, S.A., Achen, M.G., Alitalo, K., Christofori, G. Am. J. Pathol. (2007) [Pubmed]
  4. Peutz-Jeghers syndrome: clinicopathology and molecular alterations. McGarrity, T.J., Amos, C. Cell. Mol. Life Sci. (2006) [Pubmed]
  5. Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. Imanishi, Y., Gerke, V., Palczewski, K. J. Cell Biol. (2004) [Pubmed]
  6. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. Sztalryd, C., Xu, G., Dorward, H., Tansey, J.T., Contreras, J.A., Kimmel, A.R., Londos, C. J. Cell Biol. (2003) [Pubmed]
  7. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Tansey, J.T., Sztalryd, C., Gruia-Gray, J., Roush, D.L., Zee, J.V., Gavrilova, O., Reitman, M.L., Deng, C.X., Li, C., Kimmel, A.R., Londos, C. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Reproduction study of carteolol hydrochloride in mice. Part 2. Peri -and postnatal toxicity. Tamagawa, M., Numoto, T., Tanaka, N., Nishino, H. The Journal of toxicological sciences. (1979) [Pubmed]
  9. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. Miyoshi, H., Souza, S.C., Zhang, H.H., Strissel, K.J., Christoffolete, M.A., Kovsan, J., Rudich, A., Kraemer, F.B., Bianco, A.C., Obin, M.S., Greenberg, A.S. J. Biol. Chem. (2006) [Pubmed]
  10. Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes. Miyoshi, H., Perfield, J.W., Souza, S.C., Shen, W.J., Zhang, H.H., Stancheva, Z.S., Kraemer, F.B., Obin, M.S., Greenberg, A.S. J. Biol. Chem. (2007) [Pubmed]
  11. Identification of Mouse Prp19p as a Lipid Droplet-associated Protein and Its Possible Involvement in the Biogenesis of Lipid Droplets. Cho, S.Y., Shin, E.S., Park, P.J., Shin, D.W., Chang, H.K., Kim, D., Lee, H.H., Lee, J.H., Kim, S.H., Song, M.J., Chang, I.S., Lee, O.S., Lee, T.R. J. Biol. Chem. (2007) [Pubmed]
  12. The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. Arimura, N., Horiba, T., Imagawa, M., Shimizu, M., Sato, R. J. Biol. Chem. (2004) [Pubmed]
  13. Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. Subramanian, V., Rothenberg, A., Gomez, C., Cohen, A.W., Garcia, A., Bhattacharyya, S., Shapiro, L., Dolios, G., Wang, R., Lisanti, M.P., Brasaemle, D.L. J. Biol. Chem. (2004) [Pubmed]
  14. Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line. Sztalryd, C., Bell, M., Lu, X., Mertz, P., Hickenbottom, S., Chang, B.H., Chan, L., Kimmel, A.R., Londos, C. J. Biol. Chem. (2006) [Pubmed]
  15. Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis. Kovsan, J., Ben-Romano, R., Souza, S.C., Greenberg, A.S., Rudich, A. J. Biol. Chem. (2007) [Pubmed]
  16. TNF-alpha induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. Souza, S.C., Palmer, H.J., Kang, Y.H., Yamamoto, M.T., Muliro, K.V., Paulson, K.E., Greenberg, A.S. J. Cell. Biochem. (2003) [Pubmed]
  17. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. Souza, S.C., Muliro, K.V., Liscum, L., Lien, P., Yamamoto, M.T., Schaffer, J.E., Dallal, G.E., Wang, X., Kraemer, F.B., Obin, M., Greenberg, A.S. J. Biol. Chem. (2002) [Pubmed]
  18. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts. Imamura, M., Inoguchi, T., Ikuyama, S., Taniguchi, S., Kobayashi, K., Nakashima, N., Nawata, H. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  19. Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels. Ke, Y., Qiu, J., Ogus, S., Shen, W.J., Kraemer, F.B., Chehab, F.F. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. The central domain is required to target and anchor perilipin A to lipid droplets. Garcia, A., Sekowski, A., Subramanian, V., Brasaemle, D.L. J. Biol. Chem. (2003) [Pubmed]
  21. Magnolol stimulates lipolysis in lipid-laden RAW 264.7 macrophages. Chen, J.S., Chen, Y.L., Greenberg, A.S., Chen, Y.J., Wang, S.M. J. Cell. Biochem. (2005) [Pubmed]
  22. Modulatory influence of Rosemarinus officinalis on DMBA-induced mouse skin tumorigenesis. Sancheti, G., Goyal, P. Asian Pac. J. Cancer Prev. (2006) [Pubmed]
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