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Gene Review

Abcg8  -  ATP-binding cassette, sub-family G (WHITE)...

Mus musculus

Synonyms: 1300003C16Rik, AI114946, ATP-binding cassette sub-family G member 8, Sterolin-2, sterolin-2
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High impact information on Abcg8

  • Hepatic expression of Abcg8 was reduced by about 35% in Abcg5-deficient mice when compared with controls [1].
  • Higher hepatic messenger RNA expression of Abcg5 and Abcg8 in strain PERA/Ei correlates positively with higher biliary cholesterol levels [2].
  • Thus Abcg5 and Abcg8 are required for LXR agonist-associated changes in dietary and biliary sterol trafficking [3].
  • Indeed, isolation of canalicular membranes revealed a reduction of 45% in cholesterol content under these conditions in Abcg8(-/-) mice [4].
  • Haplotype analysis narrowed this QTL, and sequencing of the candidate genes Abcg5 and Abcg8 confirmed shared alleles in strains I/LnJ and DBA/2J that differed from the alleles in strain PERA/EiJ [5].

Anatomical context of Abcg8


Associations of Abcg8 with chemical compounds


Other interactions of Abcg8


  1. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Plösch, T., Bloks, V.W., Terasawa, Y., Berdy, S., Siegler, K., Van Der Sluijs, F., Kema, I.P., Groen, A.K., Shan, B., Kuipers, F., Schwarz, M., Schwartz, M. Gastroenterology (2004) [Pubmed]
  2. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Wittenburg, H., Lyons, M.A., Li, R., Churchill, G.A., Carey, M.C., Paigen, B. Gastroenterology (2003) [Pubmed]
  3. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. Yu, L., York, J., von Bergmann, K., Lutjohann, D., Cohen, J.C., Hobbs, H.H. J. Biol. Chem. (2003) [Pubmed]
  4. The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. Kosters, A., Kunne, C., Looije, N., Patel, S.B., Oude Elferink, R.P., Groen, A.K. J. Lipid Res. (2006) [Pubmed]
  5. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. Wittenburg, H., Lyons, M.A., Li, R., Kurtz, U., Wang, X., Mössner, J., Churchill, G.A., Carey, M.C., Paigen, B. J. Lipid Res. (2006) [Pubmed]
  6. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. Kosters, A., Frijters, R.J., Schaap, F.G., Vink, E., Plösch, T., Ottenhoff, R., Jirsa, M., De Cuyper, I.M., Kuipers, F., Groen, A.K. J. Hepatol. (2003) [Pubmed]
  7. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. Duan, L.P., Wang, H.H., Wang, D.Q. J. Lipid Res. (2004) [Pubmed]
  8. A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. Klett, E.L., Lu, K., Kosters, A., Vink, E., Lee, M.H., Altenburg, M., Shefer, S., Batta, A.K., Yu, H., Chen, J., Klein, R., Looije, N., Oude-Elferink, R., Groen, A.K., Maeda, N., Salen, G., Patel, S.B. BMC medicine [electronic resource]. (2004) [Pubmed]
  9. Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects. Duan, L.P., Wang, H.H., Ohashi, A., Wang, D.Q. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
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