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Gene Review

Chab1  -  cholesterol absorption 1

Mus musculus

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Disease relevance of Chab1


High impact information on Chab1


Chemical compound and disease context of Chab1


Biological context of Chab1


Anatomical context of Chab1


Associations of Chab1 with chemical compounds


Regulatory relationships of Chab1


Other interactions of Chab1


Analytical, diagnostic and therapeutic context of Chab1


  1. Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice. Richmond, B.L., Boileau, A.C., Zheng, S., Huggins, K.W., Granholm, N.A., Tso, P., Hui, D.Y. Gastroenterology (2001) [Pubmed]
  2. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Garcia-Calvo, M., Lisnock, J., Bull, H.G., Hawes, B.E., Burnett, D.A., Braun, M.P., Crona, J.H., Davis, H.R., Dean, D.C., Detmers, P.A., Graziano, M.P., Hughes, M., Macintyre, D.E., Ogawa, A., O'neill, K.A., Iyer, S.P., Shevell, D.E., Smith, M.M., Tang, Y.S., Makarewicz, A.M., Ujjainwalla, F., Altmann, S.W., Chapman, K.T., Thornberry, N.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. McNeish, J., Aiello, R.J., Guyot, D., Turi, T., Gabel, C., Aldinger, C., Hoppe, K.L., Roach, M.L., Royer, L.J., de Wet, J., Broccardo, C., Chimini, G., Francone, O.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. Xie, Y., Newberry, E.P., Young, S.G., Robine, S., Hamilton, R.L., Wong, J.S., Luo, J., Kennedy, S., Davidson, N.O. J. Biol. Chem. (2006) [Pubmed]
  5. Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol. Uchida, K., Takase, H., Nomura, Y., Takeda, K., Takeuchi, N., Ishikawa, Y. J. Lipid Res. (1984) [Pubmed]
  6. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Repa, J.J., Turley, S.D., Lobaccaro, J.A., Medina, J., Li, L., Lustig, K., Shan, B., Heyman, R.A., Dietschy, J.M., Mangelsdorf, D.J. Science (2000) [Pubmed]
  7. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. Wang, D.Q., Schmitz, F., Kopin, A.S., Carey, M.C. J. Clin. Invest. (2004) [Pubmed]
  8. Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet-induced hyperbetalipoproteinemia. Wölle, S., Via, D.P., Chan, L., Cornicelli, J.A., Bisgaier, C.L. J. Clin. Invest. (1995) [Pubmed]
  9. Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice. Wang, H.H., Afdhal, N.H., Gendler, S.J., Wang, D.Q. Gastroenterology (2006) [Pubmed]
  10. Genetic factors at the enterocyte level account for variations in intestinal cholesterol absorption efficiency among inbred strains of mice. Wang, D.Q., Paigen, B., Carey, M.C. J. Lipid Res. (2001) [Pubmed]
  11. Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia. Schwarz, M., Russell, D.W., Dietschy, J.M., Turley, S.D. J. Lipid Res. (1998) [Pubmed]
  12. Cholesterol gallstones in alloxan-diabetic mice. Akiyoshi, T., Uchida, K., Takase, H., Nomura, Y., Takeuchi, N. J. Lipid Res. (1986) [Pubmed]
  13. Genetic analysis of intestinal cholesterol absorption in inbred mice. Schwarz, M., Davis, D.L., Vick, B.R., Russell, D.W. J. Lipid Res. (2001) [Pubmed]
  14. apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes. Huang, L.S., Voyiaziakis, E., Markenson, D.F., Sokol, K.A., Hayek, T., Breslow, J.L. J. Clin. Invest. (1995) [Pubmed]
  15. Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers. Eckhardt, E.R., Wang, D.Q., Donovan, J.M., Carey, M.C. Gastroenterology (2002) [Pubmed]
  16. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Joseph, S.B., McKilligin, E., Pei, L., Watson, M.A., Collins, A.R., Laffitte, B.A., Chen, M., Noh, G., Goodman, J., Hagger, G.N., Tran, J., Tippin, T.K., Wang, X., Lusis, A.J., Hsueh, W.A., Law, R.E., Collins, J.L., Willson, T.M., Tontonoz, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. Davis, H.R., Zhu, L.J., Hoos, L.M., Tetzloff, G., Maguire, M., Liu, J., Yao, X., Iyer, S.P., Lam, M.H., Lund, E.G., Detmers, P.A., Graziano, M.P., Altmann, S.W. J. Biol. Chem. (2004) [Pubmed]
  18. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. Cases, S., Novak, S., Zheng, Y.W., Myers, H.M., Lear, S.R., Sande, E., Welch, C.B., Lusis, A.J., Spencer, T.A., Krause, B.R., Erickson, S.K., Farese, R.V. J. Biol. Chem. (1998) [Pubmed]
  19. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse. Woollett, L.A., Osono, Y., Herz, J., Dietschy, J.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Caveolin-1 is not required for murine intestinal cholesterol transport. Valasek, M.A., Weng, J., Shaul, P.W., Anderson, R.G., Repa, J.J. J. Biol. Chem. (2005) [Pubmed]
  21. Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice. Dawson, P.A., Haywood, J., Craddock, A.L., Wilson, M., Tietjen, M., Kluckman, K., Maeda, N., Parks, J.S. J. Biol. Chem. (2003) [Pubmed]
  22. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. Kaneko, E., Matsuda, M., Yamada, Y., Tachibana, Y., Shimomura, I., Makishima, M. J. Biol. Chem. (2003) [Pubmed]
  23. In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs. Hawes, B.E., O'neill, K.A., Yao, X., Crona, J.H., Davis, H.R., Graziano, M.P., Altmann, S.W. Mol. Pharmacol. (2007) [Pubmed]
  24. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. Howles, P.N., Carter, C.P., Hui, D.Y. J. Biol. Chem. (1996) [Pubmed]
  25. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. Temel, R.E., Lee, R.G., Kelley, K.L., Davis, M.A., Shah, R., Sawyer, J.K., Wilson, M.D., Rudel, L.L. J. Lipid Res. (2005) [Pubmed]
  26. Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Kruit, J.K., Plösch, T., Havinga, R., Boverhof, R., Groot, P.H., Groen, A.K., Kuipers, F. Gastroenterology (2005) [Pubmed]
  27. Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. Knight, B.L., Patel, D.D., Humphreys, S.M., Wiggins, D., Gibbons, G.F. J. Lipid Res. (2003) [Pubmed]
  28. Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. Schwarz, M., Russell, D.W., Dietschy, J.M., Turley, S.D. J. Lipid Res. (2001) [Pubmed]
  29. Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1. van der Veen, J.N., Kruit, J.K., Havinga, R., Baller, J.F., Chimini, G., Lestavel, S., Staels, B., Groot, P.H., Groen, A.K., Kuipers, F. J. Lipid Res. (2005) [Pubmed]
  30. ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. Drobnik, W., Lindenthal, B., Lieser, B., Ritter, M., Christiansen Weber, T., Liebisch, G., Giesa, U., Igel, M., Borsukova, H., Büchler, C., Fung-Leung, W.P., Von Bergmann, K., Schmitz, G. Gastroenterology (2001) [Pubmed]
  31. A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. Mouzeyan, A., Choi, J., Allayee, H., Wang, X., Sinsheimer, J., Phan, J., Castellani, L.W., Reue, K., Lusis, A.J., Davis, R.C. J. Lipid Res. (2000) [Pubmed]
  32. Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine. Voshol, P.J., Schwarz, M., Rigotti, A., Krieger, M., Groen, A.K., Kuipers, F. Biochem. J. (2001) [Pubmed]
  33. Evidence that leptin contributes to intestinal cholesterol absorption in obese (ob/ob) mice and wild-type mice. Igel, M., Lindenthal, B., Giesa, U., von, B.K. Lipids (2002) [Pubmed]
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