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Gene Review

NEK4  -  NIMA-related kinase 4

Homo sapiens

Synonyms: NRK2, Never in mitosis A-related kinase 4, NimA-related protein kinase 4, STK2, Serine/threonine-protein kinase 2, ...
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Disease relevance of NEK4


High impact information on NEK4

  • Northern analysis shows preferential expression of nek3 in mitotically active tissue, whereas nek4 is highly abundant in the testis [2].

Biological context of NEK4


Analytical, diagnostic and therapeutic context of NEK4

  • They used a type UDP-10 Sonopan, with a sound acquisition system and graphic of recording on a 6 NEK-4 polyrecorder for registration of the carotid D curves together with ECG and phonocardiogram [3].


  1. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Levedakou, E.N., He, M., Baptist, E.W., Craven, R.J., Cance, W.G., Welcsh, P.L., Simmons, A., Naylor, S.L., Leach, R.J., Lewis, T.B. Oncogene (1994) [Pubmed]
  2. NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3. Chen, A., Yanai, A., Arama, E., Kilfin, G., Motro, B. Gene (1999) [Pubmed]
  3. Study of the cerebral vascular Doppler velocimetry and EEG in a group of 18 cases of Alzheimer's disease. Gusti, S.I., Coteanu, M.I., Gusti, A.S. Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale]. (2004) [Pubmed]
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