Disease relevance of STRN

• The polymerase (L) protein of rinderpest virus interacts with the host cell protein striatin [1] .

High impact information on STRN

• As analyzed by Northern blots, in situ hybridization, and immunocytochemistry, striatin is localized in the central nervous system, where it is confined to a subset of neurons, many of which are associated with the motor system [2].
• Proteins of the striatin family have been identified in all multicellular animals [3]
• Furthermore, striatin is essentially found in dendrites, but not in axons, and is most abundant in dendritic spines [2].
• Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha [4].
• These findings identify striatin as a molecular scaffold required for rapid, nongenomic estrogen-mediated activation of downstream signaling pathways [4].
• Striatin directly binds to amino acids 183-253 of ERalpha, targets ERalpha to the cell membrane, and serves as a scaffold for the formation of an ERalpha-Galphai complex [4].

Biological context of STRN

• Since the Caenorabditis elegans genome also contains a closely related striatin coding sequence, the function of striatin is likely to be well conserved [5].
• A WD40 repeat protein regulates fungal cell differentiation and can be replaced functionally by the mammalian homologue striatin [6].
• PRO11 shows significant homology to several vertebrate WD40 proteins, such as striatin and zinedin, which seem to be involved in Ca2+-dependent signaling in cells of the central nervous system and are supposed to function as scaffolding proteins linking signaling and eukaryotic endocytosis [6] .

Anatomical context of STRN

• Hence, it is likely that the proteins of the striatin family are addressed to membrane microdomains by their binding to caveolin, in accordance with their putative role in membrane trafficking [Baillat et al. (2001) Mol. Biol. Cell 12, 663-673] [7].

Analytical, diagnostic and therapeutic context of STRN

• Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain [5].
• The L domain with which striatin interacts was investigated by co-immunoprecipitation and striatin was shown to interact primarily with the central conserved domain [1].

References