Psychiatry related information on Strn

• Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity [1].

High impact information on Strn

• Phocein, an intracellular protein interacting with striatin, bears a few homologies with the varsigma-subunits of clathrin adaptor proteins (Baillat, G., Moqrich, A., Castets, F., Baude, A., Bailly, Y., Benmerah, A., and Monneron, A. (2001) Mol. Biol. Cell 12, 663-673) [2].
• In the presence of Ca2+, the equilibrium dissociation constant of calmodulin/striatin fusion protein complex is 40 +/- 5 nM [3].
• Generally associated with membranes, striatin is mostly found in dendritic spines where it is likely to play a role in Ca2+-signaling events [3].
• This model allows analysis of the molecular basis of striatin function in the dynamic changes occurring in growing dendrites, and offers clues to unravel its function within spines [1].
• To approach the cellular mechanisms in which striatin is involved, striatin down-regulation was studied in a comparatively simpler model: purified rat spinal motoneurons which retain their polarity in culture [1].

Biological context of Strn

• But, at the dendritic spine level, striatin may be involved in signal transduction mechanisms involving as yet unidentified excitatory afferents to striatal neurons [4].

Anatomical context of Strn

• Data also indicate a preferential relationship between striatin-containing structures and afferents from the parafascicular thalamic nucleus with respect to the frontoparietal cerebral cortex [4].
• Anterograde tract-tracing by means of biotinylated dextran amine injection in the frontoparietal cerebral cortex or the parafascicular nucleus of the thalamus was combined with immunogold detection of striatin [4].
• We examined the distribution of striatin and its mRNA in the rat central nervous system (CNS) by using immunocytochemistry and in situ hybridization, respectively [5].
• Except for the medial forebrain bundle, all axonal fiber tracts examined are devoid of striatin immunolabeling [5].
• In the cell bodies and dendrites, striatin labelling was usually not associated with the cytoplasmic membrane nor with the postsynaptic densities [4].

Associations of Strn with chemical compounds

• Phocein and members of the striatin family (striatin, SG2NA and zinedin) are intracellular proteins, mainly expressed in neurones of the mammalian central nervous system where they are thought to be involved in vesicular traffic and Ca(2+) signalling [6].

Other interactions of Strn

• We also show that brain striatin subcellular localization, as studied by tissue fractionation, is Ca2+-dependent, this effect being probably mediated by calmodulin [3].

Analytical, diagnostic and therapeutic context of Strn

• Our results are in agreement with the hypothesis that striatin is a transducer involved in Ca2+ signaling or an adapter protein involved in regulating macromolecular assemblies within dendritic spines [3].
• RT-PCR experiments showed that mRNAs of phocein, striatin, SG2NA and zinedin are present in all studied peripheral ganglia [6].
• Immunoblotting experiments confirm these data and in addition demonstrate that: (1) the proteins phocein, striatin and SG2NA are also present in the superior cervical ganglion and (2) zinedin is detected in all studied ganglia [6].

References