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Gene Review

Trap1  -  TNF receptor-associated protein 1

Mus musculus

Synonyms: 2410002K23Rik, HSP 75, HSP75, Heat shock protein 75 kDa, mitochondrial, Hsp75, ...
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Disease relevance of Trap1

  • The provirus was found to have integrated adjacent to the promoter of a novel mouse gene (TRAP1) that was expressed at low levels in various mouse tissues [1].

High impact information on Trap1


Biological context of Trap1


Physical interactions of Trap1


Regulatory relationships of Trap1

  • Thus, TLR4 signaling is composed of at least two distinct pathways, a MyD88-dependent pathway that is critical to the induction of inflammatory cytokines and a MyD88/TNFR-associated factor 6-independent pathway that regulates induction of IP-10 [8].


  1. A replication-competent promoter-trap retrovirus. Coulombe, J., Avis, Y., Gray, D.A. J. Virol. (1996) [Pubmed]
  2. Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis. Ordway, D., Harton, M., Henao-Tamayo, M., Montoya, R., Orme, I.M., Gonzalez-Juarrero, M. J. Immunol. (2006) [Pubmed]
  3. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. Andrade, R.M., Wessendarp, M., Portillo, J.A., Yang, J.Q., Gomez, F.J., Durbin, J.E., Bishop, G.A., Subauste, C.S. J. Immunol. (2005) [Pubmed]
  4. Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis. Zhang, Z., Jimi, E., Bothwell, A.L. J. Immunol. (2003) [Pubmed]
  5. Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction. Haxhinasto, S.A., Hostager, B.S., Bishop, G.A. J. Immunol. (2002) [Pubmed]
  6. TNF-alpha is the critical mediator of the cyclic AMP-induced apoptosis of CD8+4+ double-positive thymocytes. Guevara Patiño, J.A., Ivanov, V.N., Lacy, E., Elkon, K.B., Marino, M.W., Nikolic-Zugić, J. J. Immunol. (2000) [Pubmed]
  7. Identification of the divergent calmodulin binding motif in yeast Ssb1/Hsp75 protein and in other HSP70 family members. Heinen, R.C., Diniz-Mendes, L., Silva, J.T., Paschoalin, V.M. Braz. J. Med. Biol. Res. (2006) [Pubmed]
  8. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Mühlradt, P.F., Sato, S., Hoshino, K., Akira, S. J. Immunol. (2001) [Pubmed]
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