Gene Review:
Cxcl10 - chemokine (C-X-C motif) ligand 10
Mus musculus
Synonyms:
10 kDa interferon gamma-induced protein, C-X-C motif chemokine 10, C7, CRG-2, Crg2, ...
- IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. Dufour, J.H., Dziejman, M., Liu, M.T., Leung, J.H., Lane, T.E., Luster, A.D. J. Immunol. (2002)
- T Cell Antiviral Effector Function Is Not Dependent on CXCL10 Following Murine Coronavirus Infection. Stiles, L.N., Hardison, J.L., Schaumburg, C.S., Whitman, L.M., Lane, T.E. J. Immunol. (2006)
- Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. Hsieh, M.F., Lai, S.L., Chen, J.P., Sung, J.M., Lin, Y.L., Wu-Hsieh, B.A., Gerard, C., Luster, A., Liao, F. J. Immunol. (2006)
- Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice. Hasegawa, H., Inoue, A., Kohno, M., Muraoka, M., Miyazaki, T., Terada, M., Nakayama, T., Yoshie, O., Nose, M., Yasukawa, M. Arthritis Rheum. (2006)
- CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. Trifilo, M.J., Montalto-Morrison, C., Stiles, L.N., Hurst, K.R., Hardison, J.L., Manning, J.E., Masters, P.S., Lane, T.E. J. Virol. (2004)
- IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Khan, I.A., MacLean, J.A., Lee, F.S., Casciotti, L., DeHaan, E., Schwartzman, J.D., Luster, A.D. Immunity (2000)
- Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. Okabe, Y., Kawane, K., Akira, S., Taniguchi, T., Nagata, S. J. Exp. Med. (2005)
- Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes. Yoneyama, H., Narumi, S., Zhang, Y., Murai, M., Baggiolini, M., Lanzavecchia, A., Ichida, T., Asakura, H., Matsushima, K. J. Exp. Med. (2002)
- CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice. Shigihara, T., Shimada, A., Oikawa, Y., Yoneyama, H., Kanazawa, Y., Okubo, Y., Matsushima, K., Yamato, E., Miyazaki, J., Kasuga, A., Saruta, T., Narumi, S. J. Immunol. (2005)
- Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Tager, A.M., Kradin, R.L., LaCamera, P., Bercury, S.D., Campanella, G.S., Leary, C.P., Polosukhin, V., Zhao, L.H., Sakamoto, H., Blackwell, T.S., Luster, A.D. Am. J. Respir. Cell Mol. Biol. (2004)
- Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms. Schaefer, K.L., Denevich, S., Ma, C., Cooley, S.R., Nakajima, A., Wada, K., Schlezinger, J., Sherr, D., Saubermann, L.J. Inflamm. Bowel Dis. (2005)
- Synthesis and antitumor activity of duocarmycin derivatives: modification at the C-7 position of segment-A of A-ring pyrrole compounds. Amishiro, N., Okamoto, A., Okabe, M., Saito, H. Bioorg. Med. Chem. (2000)
- IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. Klein, R.S., Izikson, L., Means, T., Gibson, H.D., Lin, E., Sobel, R.A., Weiner, H.L., Luster, A.D. J. Immunol. (2004)
- Tissue-specific expression of murine IP-10 mRNA following systemic treatment with interferon gamma. Narumi, S., Wyner, L.M., Stoler, M.H., Tannenbaum, C.S., Hamilton, T.A. J. Leukoc. Biol. (1992)
- Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Zeng, X., Moore, T.A., Newstead, M.W., Deng, J.C., Kunkel, S.L., Luster, A.D., Standiford, T.J. Infect. Immun. (2005)
- Interferon regulatory factor-1 down-regulates cytokine-induced IP-10 expression in pancreatic islets. Baker, M.S., Chen, X., Rotramel, A.R., Nelson, J.J., Kaufman, D.B. Surgery (2003)
- Donor-derived IP-10 initiates development of acute allograft rejection. Hancock, W.W., Gao, W., Csizmadia, V., Faia, K.L., Shemmeri, N., Luster, A.D. J. Exp. Med. (2001)
- Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. Horton, M.R., McKee, C.M., Bao, C., Liao, F., Farber, J.M., Hodge-DuFour, J., Puré, E., Oliver, B.L., Wright, T.M., Noble, P.W. J. Biol. Chem. (1998)
- Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. Christen, U., McGavern, D.B., Luster, A.D., von Herrath, M.G., Oldstone, M.B. J. Immunol. (2003)
- Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Harari, O.A., Alcaide, P., Ahl, D., Luscinskas, F.W., Liao, J.K. Circ. Res. (2006)
- Interleukin-10 suppresses IP-10 gene transcription by inhibiting the production of class I interferon. Tebo, J.M., Kim, H.S., Gao, J., Armstrong, D.A., Hamilton, T.A. Blood (1998)
- IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. Medoff, B.D., Sauty, A., Tager, A.M., Maclean, J.A., Smith, R.N., Mathew, A., Dufour, J.H., Luster, A.D. J. Immunol. (2002)
- Cytokine-responsive gene-2/IFN-inducible protein-10 expression in multiple models of liver and bile duct injury suggests a role in tissue regeneration. Koniaris, L.G., Zimmers-Koniaris, T., Hsiao, E.C., Chavin, K., Sitzmann, J.V., Farber, J.M. J. Immunol. (2001)
- Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848). McCluskie, M.J., Cartier, J.L., Patrick, A.J., Sajic, D., Weeratna, R.D., Rosenthal, K.L., Davis, H.L. Antiviral Res. (2006)
- Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. Chen, J.P., Lu, H.L., Lai, S.L., Campanella, G.S., Sung, J.M., Lu, M.Y., Wu-Hsieh, B.A., Lin, Y.L., Lane, T.E., Luster, A.D., Liao, F. J. Immunol. (2006)
- Expression of IP-10, a lipopolysaccharide- and interferon-gamma-inducible protein, in murine mesangial cells in culture. Gómez-Chiarri, M., Hamilton, T.A., Egido, J., Emancipator, S.N. Am. J. Pathol. (1993)
- Early up-regulation of CXC-chemokine expression is associated with strong cellular immune responses to murine skin xenografts. Lee, E.M., Park, J.O., Kim, D., Kim, J.Y., Oh, K.H., Park, C.G., Oh, B.H., Kim, S., Ahn, C. Xenotransplantation (2006)
- CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. Christensen, J.E., de Lemos, C., Moos, T., Christensen, J.P., Thomsen, A.R. J. Immunol. (2006)
- TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Qian, C., An, H., Yu, Y., Liu, S., Cao, X. Blood (2007)
- Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt, G.C., Corrion, L.A., Olkiewicz, K.M., Lu, B., Lowler, K., Duffner, U.A., Moore, B.B., Kuziel, W.A., Liu, C., Cooke, K.R. J. Immunol. (2004)
- Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression. Fischer, F.R., Santambrogio, L., Luo, Y., Berman, M.A., Hancock, W.W., Dorf, M.E. J. Neuroimmunol. (2000)
- Chemokine CXCL10 (IP-10) is sufficient to trigger an immune response to injected antigens in a mouse model. Krathwohl, M.D., Anderson, J.L. Vaccine (2006)
- Elevated interferon gamma expression in the central nervous system of tumour necrosis factor receptor 1-deficient mice with experimental autoimmune encephalomyelitis. Wheeler, R.D., Zehntner, S.P., Kelly, L.M., Bourbonnière, L., Owens, T. Immunology (2006)