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Gene Review

TPM4  -  tropomyosin 4

Homo sapiens

Synonyms: TM30p1, Tropomyosin alpha-4 chain, Tropomyosin-4
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Disease relevance of TPM4


High impact information on TPM4


Biological context of TPM4


Analytical, diagnostic and therapeutic context of TPM4

  • Differential expression was confirmed for four proteins including PDX6, CRAB, TPM4, and HSP60 by real-time quantitative PCR and Western blotting analysis in our model [1].


  1. Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry. Li, D.Q., Wang, L., Fei, F., Hou, Y.F., Luo, J.M., Zeng, R., Wu, J., Lu, J.S., Di, G.H., Ou, Z.L., Xia, Q.C., Shen, Z.Z., Shao, Z.M. Proteomics (2006) [Pubmed]
  2. Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion. Meech, S.J., McGavran, L., Odom, L.F., Liang, X., Meltesen, L., Gump, J., Wei, Q., Carlsen, S., Hunger, S.P. Blood (2001) [Pubmed]
  3. Isolation and characterization of related cDNA clones encoding skeletal muscle beta-tropomyosin and a low-molecular-weight nonmuscle tropomyosin isoform. Bradac, J.A., Gruber, C.E., Forry-Schaudies, S., Hughes, S.H. Mol. Cell. Biol. (1989) [Pubmed]
  4. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Lawrence, B., Perez-Atayde, A., Hibbard, M.K., Rubin, B.P., Dal Cin, P., Pinkus, J.L., Pinkus, G.S., Xiao, S., Yi, E.S., Fletcher, C.D., Fletcher, J.A. Am. J. Pathol. (2000) [Pubmed]
  5. Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin. MacLeod, A.R., Talbot, K., Smillie, L.B., Houlker, C. J. Mol. Biol. (1987) [Pubmed]
  6. Tropomyosin 3 increases striated muscle isoform diversity. Pieples, K., Wieczorek, D.F. Biochemistry (2000) [Pubmed]
  7. Identification of differentially expressed genes in primary varicose veins. Kim, D.I., Eo, H.S., Joh, J.H. J. Surg. Res. (2005) [Pubmed]
  8. Assignment of the human alpha-tropomyosin gene TPM4 to band 19p13.1 by fluorescence in situ hybridization. Wilton, S.D., Lim, L., Dorosz, S.D., Gunn, H.C., Eyre, H.J., Callen, D.F., Laing, N.G. Cytogenet. Cell Genet. (1996) [Pubmed]
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