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Gene Review:

ZNF165 - zinc finger protein 165

Homo sapiens

Synonyms: CT53, Cancer/testis antigen 53, LD65, ZPF165, ZSCAN7, ...

Dong, X.Y. et al., Tirosvoutis, K.N. et al., Paoloni-Giacobino, A. et al.

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Disease relevance of ZNF165

RT-PCR, real-time PCR and Northern blotting analysis confirmed that ZNF165 mRNA was expressed in the hepatocellular carcinoma, gastric cancer, colon cancer and non-small-cell lung carcinoma [1].

High impact information on ZNF165

The nucleotide sequence of ZNF165 expressed in tumours is identical to that expressed in the testis [1].
Analysis of the origins of publicly available expressed sequence tags as presented in Unigene and SAGE databases revealed that ZNF165 mRNA was expressed in tumours of different tissues [1].
Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis [2].
Analysis of somatic cell hybrids containing single human chromosomes shows that ZNF165 maps to chromosome 6 [2].
Fluorescence in situ hybridization of cDNA insert probes to male metaphase spreads shows that the ZNF165 transcript maps to 6p21 close to the human MHC region [2].

Analytical, diagnostic and therapeutic context of ZNF165

1. Southern blot analysis showed that the gene ZNF165, which maps to this region and which is specifically expressed in the testis, was not disrupted by the translocation [3].

References

Zinc-finger protein ZNF165 is a novel cancer-testis antigen capable of eliciting antibody response in hepatocellular carcinoma patients. Dong, X.Y., Yang, X.A., Wang, Y.D., Chen, W.F. Br. J. Cancer (2004) [Pubmed]
Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. Tirosvoutis, K.N., Divane, A., Jones, M., Affara, N.A. Genomics (1995) [Pubmed]
Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility. Paoloni-Giacobino, A., Kern, I., Rumpler, Y., Djlelati, R., Morris, M.A., Dahoun, S.P. Clin. Genet. (2000) [Pubmed]

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