The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PHC3  -  polyhomeotic homolog 3 (Drosophila)

Homo sapiens

Synonyms: EDR3, Early development regulatory protein 3, FLJ12729, FLJ12967, HPH3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PHC3


High impact information on PHC3

  • Apart from the proximal promoter region, three highly homologous (PH1 to PH3) sequences were apparent in the human and mouse 5' flanking regions of the gene [3].
  • DFT and TD-DFT calculations have been performed on trans-[Ru(L')4(C[triple bond]CAr)2](0/+) (L' = PH3 and NH3) to examine the metal-acetylide pi-interaction and the nature of the associated electronic transition(s) [4].
  • In this theoretical study on rhodium-catalysed hydroformylation we examine an unmodified hydridorhodium(I) carbonyl system a together with three variants modified by the model phosphane ligands PF3 (system b), PH3 (system c) and PMe3 (system d), which show increasing basicity on the Tolman chi parameter scale [5].
  • Significant growth occurred beyond stages PH3 (PH4 6.54 mm, PH5 8.98 mm) and B3 (B4 7.25 mm, B5 9.41 mm) and from less than 1 year prior to menarche to more than 1 year after menarche (5.92 mm for girls less than 1 year premenarche, 7.88 mm for girls in their first year after menarche, and 9.05 mm for girls more than 1 year beyond menarche) [6].
  • The nature of interactions of phenol with various molecules (Y = HF, HCl, H2O, H2S, NH3, PH3, MeOH, MeSH) is investigated using ab initio calculations [7].

Biological context of PHC3

  • METHODS: We screened 71 Caucasian and 69 African American individuals for genetic variants in the promoter region, three highly conserved upstream regulatory sequences (PH1, PH2 and PH3), the human beta-cell specific enhancer, and the two exons with adjacent introns [8].
  • Thus, HPH-3 induced apoptosis in human pancreatic carcinoma cells, which is a unique characteristic among bleomycin-related compounds [1].
  • HPH-3-induced cell death was not inhibited by antioxidants such as reduced glutathione and N-acetylcysteine, whereas hydrogen peroxide-induced cell death was inhibited by them, indicating that hydrogen peroxide is not involved in the induction of apoptosis by HPH-3 [1].

Associations of PHC3 with chemical compounds

  • The mean age found for B2 was 10.30 +/- 0.28 years; for B3 was 11.01 +/- 0.16 years; for PH2 was 10.58 +/- 0.22 years; for PH3 was 11.39 +/- 0.11 years; and for menarche was 13.29 +/- 0.45 years [9].
  • No N2 was formed when PH3-NH3 mixtures were photolyzed, suggesting that the destruction of NH3 is quenched by PH3 [10].
  • Histidine-pyridine-histidine-3 (HPH-3) is an oxygen-activating ligand based on the structure of bleomycin [1].
  • On the other hand, HCl, H2S, and PH3 favor pi-type H-bonding, which are slightly favored over sigma O-, sigma H-, sigma H-type bonding, respectively [7].
  • The effects on the hyperpolarizabilities of (a) the metal center (Os, Ir, Pt); (b) the ligand environment (PH3, CO, Cl); (c) various donor and acceptor substituents (NH2, OH, Me, H, Cl, Br, I, COOMe, COOH, CN, NO2); and (d) the length of pi-conjugation were studied [11].


  1. Induction of apoptosis in human pancreatic carcinoma cells by a synthetic bleomycin-like ligand. Suginaka, R., Izui, R., Inoue, J., Muraoka, Y., Yamaguchi, K., Otsuka, M., Umezawa, K. Jpn. J. Cancer Res. (1998) [Pubmed]
  2. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Deshpande, A.M., Akunowicz, J.D., Reveles, X.T., Patel, B.B., Saria, E.A., Gorlick, R.G., Naylor, S.L., Leach, R.J., Hansen, M.F. Oncogene (2007) [Pubmed]
  3. Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression. Marshak, S., Benshushan, E., Shoshkes, M., Havin, L., Cerasi, E., Melloul, D. Mol. Cell. Biol. (2000) [Pubmed]
  4. Probing ruthenium-acetylide bonding interactions: synthesis, electrochemistry, and spectroscopic studies of acetylide-ruthenium complexes supported by tetradentate macrocyclic amine and diphosphine ligands. Wong, C.Y., Che, C.M., Chan, M.C., Han, J., Leung, K.H., Phillips, D.L., Wong, K.Y., Zhu, N. J. Am. Chem. Soc. (2005) [Pubmed]
  5. Computational approaches to activity in rhodium-catalysed hydroformylation. Gleich, D., Hutter, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  6. Nipple (papilla) development in puberty: longitudinal observations in girls. Rohn, R.D. Pediatrics (1987) [Pubmed]
  7. Phenol vs water molecule interacting with various molecules: Sigma-type, pi-type, and chi-type hydrogen bonds, interaction energies, and their energy components. Bandyopadhyay, I., Lee, H.M., Kim, K.S. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  8. Insulin Promoter Factor 1 variation is associated with type 2 diabetes in African Americans. Karim, M.A., Wang, X., Hale, T.C., Elbein, S.C. BMC Med. Genet. (2005) [Pubmed]
  9. Sexual maturation of Jerusalem schoolgirls and its association with socio-economic factors and ethnic group. Belmaker, E. Ann. Hum. Biol. (1982) [Pubmed]
  10. Mechanism of phosphine photolysis. Application to Jovian atmospheric photochemistry. Ferris, J.P., Bossard, A., Khwaja, H. J. Am. Chem. Soc. (1984) [Pubmed]
  11. NLO properties of metallabenzene-based chromophores: a time-dependent density functional study. Karton, A., Iron, M.A., van der Boom, M.E., Martin, J.M. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
WikiGenes - Universities