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Gene Review

COB  -  apocytochrome b

Naumovozyma castellii

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High impact information on COB


Biological context of COB


Anatomical context of COB


Associations of COB with chemical compounds

  • A nonsense mutation of the leucine codon 335 (TTA-->TAA), 50 residues before the normal C-terminus, blocks incorporation of heme into the apocytochrome b and prevents growth on non-fermentable substrates [10].

Analytical, diagnostic and therapeutic context of COB


  1. Mosaic organization of a mitochondrial gene: evidence from double mutants in the cytochrome b region of Saccharomyces cerevisiae. Alexander, N.J., Periman, P.S., Hanson, D.K., Mahler, H.R. Cell (1980) [Pubmed]
  2. Assembly of the mitochondrial membrane system. Processing of the apocytochrome b precursor RNAs in Saccharomyces cerevisiae D273-10B. Bonitz, S.G., Homison, G., Thalenfeld, B.E., Tzagoloff, A., Nobrega, F.G. J. Biol. Chem. (1982) [Pubmed]
  3. Expression of the "split gene" COB in yeast mtDNA. Translation of intervening sequences in mutant strains. Bechmann, H., Haid, A., Schweyen, R.J., Mathews, S., Kaudewitz, F. J. Biol. Chem. (1981) [Pubmed]
  4. Regulatory interaction between mitochondrial genes. II. Detailed characterization of novel mutants mapping within one cluster in the cob2 region. Hanson, D.K., Miller, D.H., Mahler, H.R., Alexander, N.J., Perlman, P.S. J. Biol. Chem. (1979) [Pubmed]
  5. The wheat mitochondrial gene for apocytochrome b: absence of a prokaryotic ribosome binding site. Boer, P.H., McIntosh, J.E., Gray, M.W., Bonen, L. Nucleic Acids Res. (1985) [Pubmed]
  6. Mutations in putative intervening sequences of the mitochondrial cytochrome b gene of yeast produce abnormal cytochrome b polypeptides. Solioz, M., Schatz, G. J. Biol. Chem. (1979) [Pubmed]
  7. Evidence for ribosomes involved in splicing of yeast mitochondrial transcripts. Schmelzer, C., Schweyen, R.J. Nucleic Acids Res. (1982) [Pubmed]
  8. Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b. Claros, M.G., Perea, J., Shu, Y., Samatey, F.A., Popot, J.L., Jacq, C. Eur. J. Biochem. (1995) [Pubmed]
  9. Leakiness of termination codons in mitochondrial mutants of the yeast Saccharomyces cerevisiae. Weiss-Brummer, B., Hüttenhofer, A., Kaudewitz, F. Mol. Gen. Genet. (1984) [Pubmed]
  10. The C-terminal domain of yeast cytochrome b is essential for a correct assembly of the mitochondrial cytochrome bc1 complex. di Rago, J.P., Macadre, C., Lazowska, J., Slonimski, P.P. FEBS Lett. (1993) [Pubmed]
  11. The identification of apocytochrome b as a mitochondrial gene product and immunological evidence for altered apocytochrome b in yeast strains having mutations in the COB region of mitochondrial DNA. Kreike, J., Bechmann, H., Van Hemert, F.J., Schweyen, R.J., Boer, P.H., Kaudewitz, F., Groot, G.S. Eur. J. Biochem. (1979) [Pubmed]
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