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Gene Review

COB  -  apocytochrome b

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High impact information on COB


Biological context of COB


Associations of COB with chemical compounds

  • Its NH2-terminal part is likely to be specified by sequence alpha and thus to be homologous to that of apocytochrome b [11].

Analytical, diagnostic and therapeutic context of COB


  1. ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex. Bousquet, I., Dujardin, G., Slonimski, P.P. EMBO J. (1991) [Pubmed]
  2. Antibodies against synthetic oligopeptides allow identification of the mRNA-maturase encoded by the second intron of the yeast cob-box gene. Guiso, N., Dreyfus, M., Siffert, O., Danchin, A., Spyridakis, A., Gargouri, A., Claisse, M., Slonimski, P.P. EMBO J. (1984) [Pubmed]
  3. Construction of novel cytochrome b genes in yeast mitochondria by subtraction or addition of introns. Labouesse, M., Slonimski, P.P. EMBO J. (1983) [Pubmed]
  4. Splicing of COB intron 5 requires pairing between the internal guide sequence and both flanking exons. Partono, S., Lewin, A.S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. Regulatory interactions between mitochondrial genes: interactions between two mosaic genes. Dhawale, S., Hanson, D.K., Alexander, N.J., Perlman, P.S., Mahler, H.R. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. Nucleotide sequence and intron structure of the apocytochrome b gene of Neurospora crassa mitochondria. Helmer-Citterich, M., Morelli, G., Macino, G. EMBO J. (1983) [Pubmed]
  7. Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrme oxidase. Bonitz, S.G., Coruzzi, G., Thalenfeld, B.E., Tzagoloff, A., Macino, G. J. Biol. Chem. (1980) [Pubmed]
  8. Mitochondrial and nuclear myxothiazol resistance in Saccharomyces cerevisiae. Thierbach, G., Michaelis, G. Mol. Gen. Genet. (1982) [Pubmed]
  9. Leakiness of termination codons in mitochondrial mutants of the yeast Saccharomyces cerevisiae. Weiss-Brummer, B., Hüttenhofer, A., Kaudewitz, F. Mol. Gen. Genet. (1984) [Pubmed]
  10. Interaction between mitochondrial genes in yeast: evidence for novel box effect(s). Hensgens, L.A., Van der Horst, G., Grivell, L.A. Plasmid (1984) [Pubmed]
  11. Expression of the "split gene" COB in yeast mtDNA. Translation of intervening sequences in mutant strains. Bechmann, H., Haid, A., Schweyen, R.J., Mathews, S., Kaudewitz, F. J. Biol. Chem. (1981) [Pubmed]
  12. Internal structure of a mitochondrial intron of Aspergillus nidulans. Waring, R.B., Davies, R.W., Scazzocchio, C., Brown, T.A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  13. The identification of apocytochrome b as a mitochondrial gene product and immunological evidence for altered apocytochrome b in yeast strains having mutations in the COB region of mitochondrial DNA. Kreike, J., Bechmann, H., Van Hemert, F.J., Schweyen, R.J., Boer, P.H., Kaudewitz, F., Groot, G.S. Eur. J. Biochem. (1979) [Pubmed]
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