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Gene Review

hbbe1.1  -  hemoglobin beta embryonic-1.1

Danio rerio

Synonyms: SI:dZ118J2.7, SI:dZ118J2.9, SO:0000704, bE1, hbbe1, ...
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Disease relevance of hbbe1

  • Globin X mRNA significantly decreased under hypoxia, pointing to a functional linkage to oxygen-dependent metabolism [1].
  • The solitary LTRs of ERV-9 human endogenous retrovirus are middle repetitive DNAs associated with 3,000-4,000 human gene loci including the beta-globin gene locus where the ERV-9 LTR is juxtaposed to the locus control region (beta-LCR) far upstream of the globin genes [2].

High impact information on hbbe1


Biological context of hbbe1

  • Molecular phylogenetic analysis showed that the embryonic globins were highly homologous in amino acid sequence to the embryonic globins previously identified in rainbow trout and zebrafish, and that they formed a monophyletic group among the teleostean globin molecules [6].

Analytical, diagnostic and therapeutic context of hbbe1

  • RT-PCR analysis showed that the embryonic globin mRNAs were intensely expressed in stage 30 and 38 embryos and in young fish 30 days after hatching [6].


  1. Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio). Roesner, A., Hankeln, T., Burmester, T. J. Exp. Biol. (2006) [Pubmed]
  2. The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans. Pi, W., Yang, Z., Wang, J., Ruan, L., Yu, X., Ling, J., Krantz, S., Isales, C., Conway, S.J., Lin, S., Tuan, D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Burmester, T., Ebner, B., Weich, B., Hankeln, T. Mol. Biol. Evol. (2002) [Pubmed]
  4. The tomato RNA-directed RNA polymerase has no effect on gene silencing by RNA interference in transgenic mice. de Wit, T., Grosveld, F., Drabek, D. Transgenic Res. (2002) [Pubmed]
  5. A new beta-globin gene from the zebrafish, betaE1, and its pattern of transcription during embryogenesis. Quinkertz, A., Campos-Ortega, J.A. Dev. Genes Evol. (1999) [Pubmed]
  6. Characterization and expression of embryonic and adult globins of the teleost Oryzias latipes (medaka). Maruyama, K., Yasumasu, S., Iuchi, I. J. Biochem. (2002) [Pubmed]
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