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Gene Review

Nell1  -  NEL-like 1 (chicken)

Rattus norvegicus

Synonyms: NEL-like protein 1, Protein kinase C-binding protein NELL1
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Disease relevance of Nell1


High impact information on Nell1


Biological context of Nell1


Anatomical context of Nell1

  • On a cellular level, Nell-1 expression may modulate and be both sufficient and required for osteoblast differentiation [2].

Analytical, diagnostic and therapeutic context of Nell1

  • Distracted palates of 4-week-old male rats were maintained in an organ culture system, and tissue was either unstimulated or stimulated with Nell-1 or BMP-7 for 8 days [1].
  • We also showed that Nell-1 was expressed in rat calvarial osteoprogenitor cells and was largely absent in rat tibiae and fibroblast cell cultures [4].


  1. Nell-1 induced bone formation within the distracted intermaxillary suture. Cowan, C.M., Cheng, S., Ting, K., Soo, C., Walder, B., Wu, B., Kuroda, S., Zhang, X. Bone (2006) [Pubmed]
  2. Craniosynostosis in transgenic mice overexpressing Nell-1. Zhang, X., Kuroda, S., Carpenter, D., Nishimura, I., Soo, C., Moats, R., Iida, K., Wisner, E., Hu, F.Y., Miao, S., Beanes, S., Dang, C., Vastardis, H., Longaker, M., Tanizawa, K., Kanayama, N., Saito, N., Ting, K. J. Clin. Invest. (2002) [Pubmed]
  3. Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. Zhang, X., Carpenter, D., Bokui, N., Soo, C., Miao, S., Truong, T., Wu, B., Chen, I., Vastardis, H., Tanizawa, K., Kuroda, S., Ting, K. J. Bone Miner. Res. (2003) [Pubmed]
  4. Human NELL-1 expressed in unilateral coronal synostosis. Ting, K., Vastardis, H., Mulliken, J.B., Soo, C., Tieu, A., Do, H., Kwong, E., Bertolami, C.N., Kawamoto, H., Kuroda, S., Longaker, M.T. J. Bone Miner. Res. (1999) [Pubmed]
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