The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

MRE11  -  double-strand break repair protein MRE11

Arabidopsis thaliana

Synonyms: ARABIDOPSIS MEIOTIC RECOMBINATION 11, ATMRE11, MDK4.8, MDK4_8, MEIOTIC RECOMBINATION 11
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of MRE11

 

High impact information on MRE11

  • The developmental abnormalities characteristic of bru1 mutant plants resemble those triggered by mutations in genes encoding subunits of chromatin assembly factor (CAF-1), the condensin complex, or MRE11 [2].
  • These data indicate that both Ku70 and Mre11 contribute to fusion of critically shortened telomeres in higher eucaryotes [3].
  • In triple ku70 tert mre11 mutants, chromosome fusions were still detected, but microhomology at the junction was no longer favored [3].
  • Here we describe two PCR-based methods to monitor telomere length and examine the fate of dysfunctional telomeres in Arabidopsis lacking the catalytic subunit of telomerase (TERT) and the DNA repair proteins Ku70 and Mre11 [3].
  • The Mre11 protein is essential for the long-term genetic stability of the cell and acts to ensure the efficient repair of DNA damage [1].
 

Biological context of MRE11

  • Notwithstanding the attention paid to this complex, the inviability of vertebrate rad50 and mre11 mutants has led to a relative lack of information concerning the role of these proteins in meiosis in higher eukaryotes [4].
 

Physical interactions of MRE11

  • The Rad50/Mre11/Xrs2 protein complex acts at DNA ends and is implicated in both homologous and non-homologous recombination [5].
 

Other interactions of MRE11

  • The Rad50, Mre11 and Xrs2/Nbs1 proteins, which form the highly conserved MRX complex, perform a wide range of functions concerning the maintenance and function of DNA in eukaryotes [4].

References

  1. Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants. Bundock, P., Hooykaas, P. Plant Cell (2002) [Pubmed]
  2. BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis. Takeda, S., Tadele, Z., Hofmann, I., Probst, A.V., Angelis, K.J., Kaya, H., Araki, T., Mengiste, T., Mittelsten Scheid, O., Shibahara, K., Scheel, D., Paszkowski, J. Genes Dev. (2004) [Pubmed]
  3. Molecular analysis of telomere fusions in Arabidopsis: multiple pathways for chromosome end-joining. Heacock, M., Spangler, E., Riha, K., Puizina, J., Shippen, D.E. EMBO J. (2004) [Pubmed]
  4. Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination. Bleuyard, J.Y., Gallego, M.E., White, C.I. Chromosoma (2004) [Pubmed]
  5. Homologous recombination in planta is stimulated in the absence of Rad50. Gherbi, H., Gallego, M.E., Jalut, N., Lucht, J.M., Hohn, B., White, C.I. EMBO Rep. (2001) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities