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Gene Review

MRP5  -  inositol hexakisphosphate transporter

Arabidopsis thaliana

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Disease relevance of ATMRP5


High impact information on ATMRP5

  • Using reverse genetics, we identified a plant with a T-DNA insertion in AtMRP5 (mrp5-1). mrp5-1 exhibited decreased root growth and increased lateral root formation [2].
  • In the present study, we investigated a new member of the ABC transporter superfamily of Arabidopsis thaliana, AtMRP5 [2].
  • AtMRP5 encodes a 167 kDa protein and exhibits low glutathione conjugate and glucuronide conjugate transport activity [2].
  • This observation may indicate that AtMRP5 works as an auxin conjugate transporter or that mutant plants are affected in ion uptake, which may lead to changes in auxin concentrations [2].
  • Here we show that the ATP binding cassette (ABC) protein AtMRP5 is localized to the plasma membrane [3].

Biological context of ATMRP5


Associations of ATMRP5 with chemical compounds


Other interactions of ATMRP5


  1. The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use. Klein, M., Perfus-Barbeoch, L., Frelet, A., Gaedeke, N., Reinhardt, D., Mueller-Roeber, B., Martinoia, E., Forestier, C. Plant J. (2003) [Pubmed]
  2. The Arabidopsis thaliana ABC transporter AtMRP5 controls root development and stomata movement. Gaedeke, N., Klein, M., Kolukisaoglu, U., Forestier, C., Müller, A., Ansorge, M., Becker, D., Mamnun, Y., Kuchler, K., Schulz, B., Mueller-Roeber, B., Martinoia, E. EMBO J. (2001) [Pubmed]
  3. The ATP binding cassette transporter AtMRP5 modulates anion and calcium channel activities in Arabidopsis guard cells. Suh, S.J., Wang, Y.F., Frelet, A., Leonhardt, N., Klein, M., Forestier, C., Mueller-Roeber, B., Cho, M.H., Martinoia, E., Schroeder, J.I. J. Biol. Chem. (2007) [Pubmed]
  4. Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance. Lee, E.K., Kwon, M., Ko, J.H., Yi, H., Hwang, M.G., Chang, S., Cho, M.H. Plant Physiol. (2004) [Pubmed]
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