Disease relevance of ATMRP5

• All stomatal phenotypes were complemented in transgenic mrp5-1 plants transformed with a cauliflower mosaic virus (CaMV) 35S-AtMRP5 construct [1].

High impact information on ATMRP5

• Using reverse genetics, we identified a plant with a T-DNA insertion in AtMRP5 (mrp5-1). mrp5-1 exhibited decreased root growth and increased lateral root formation [2].
• In the present study, we investigated a new member of the ABC transporter superfamily of Arabidopsis thaliana, AtMRP5 [2].
• AtMRP5 encodes a 167 kDa protein and exhibits low glutathione conjugate and glucuronide conjugate transport activity [2].
• This observation may indicate that AtMRP5 works as an auxin conjugate transporter or that mutant plants are affected in ion uptake, which may lead to changes in auxin concentrations [2].
• Here we show that the ATP binding cassette (ABC) protein AtMRP5 is localized to the plasma membrane [3].

Biological context of ATMRP5

• These observations suggest that AtMRP5 is a putative sulfonylurea receptor that is involved in K+ homeostasis and, thus, also participates in the NaCl stress response [4].
• These data provide evidence that the AtMRP5 ABC transporter is a central regulator of guard cell ion channel during abscisic acid and Ca(2+) signal transduction in guard cells [3].

Associations of ATMRP5 with chemical compounds

• Interestingly, atmrp5 insertion mutant guard cells also show impairment in abscisic acid activation of Ca(2+)-permeable channel currents in the plasma membrane of guard cells [3].

Other interactions of ATMRP5

• The plant multidrug resistance ABC transporter AtMRP5 is involved in guard cell hormonal signalling and water use [1].

References