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Gene Review

FKBP13  -  peptidyl-prolyl cis-trans isomerase FKBP13

Arabidopsis thaliana

Synonyms: ATFKBP13, FK506 BINDING PROTEIN 13, FK506-binding protein 13, MRA19.7, MRA19_7
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High impact information on AT5G45680


Biological context of AT5G45680


Anatomical context of AT5G45680

  • Experiments show that AtFKBP13 is translocated across the thylakoid membrane by the DeltapH-dependent pathway [3].

Associations of AT5G45680 with chemical compounds

  • The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling [5].
  • The TWD1 gene encodes a 42 kDa FK506-binding protein (AtFKBP42) that possesses similarity to multidomain PPIases such as mammalian FKBP51 and FKBP52, which are known to be components of mammalian steroid hormone receptor complexes [7].
  • To understand how the reduced form of AtFKBP13 is stabilized and how reduction of the cysteine residues affects the molecular properties of the enzyme, we determined the crystal structure of reduced AtFKBP13 at 1.88 A [8].

Analytical, diagnostic and therapeutic context of AT5G45680

  • The AtFKBP13 protein is synthesized as a precursor that is imported into chloroplasts and processed to the mature form located in the thylakoid lumen, as shown by chloroplast import assays and Western blot analysis [3].


  1. A redox-active FKBP-type immunophilin functions in accumulation of the photosystem II supercomplex in Arabidopsis thaliana. Lima, A., Lima, S., Wong, J.H., Phillips, R.S., Buchanan, B.B., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen. Gopalan, G., He, Z., Balmer, Y., Romano, P., Gupta, R., Héroux, A., Buchanan, B.B., Swaminathan, K., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. A chloroplast FKBP interacts with and affects the accumulation of Rieske subunit of cytochrome bf complex. Gupta, R., Mould, R.M., He, Z., Luan, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii. Crespo, J.L., Díaz-Troya, S., Florencio, F.J. Plant Physiol. (2005) [Pubmed]
  5. The ULTRACURVATA2 gene of Arabidopsis encodes an FK506-binding protein involved in auxin and brassinosteroid signaling. Pérez-Pérez, J.M., Ponce, M.R., Micol, J.L. Plant Physiol. (2004) [Pubmed]
  6. The immunophilin-interacting protein AtFIP37 from Arabidopsis is essential for plant development and is involved in trichome endoreduplication. Vespa, L., Vachon, G., Berger, F., Perazza, D., Faure, J.D., Herzog, M. Plant Physiol. (2004) [Pubmed]
  7. Characterization of Arabidopsis thaliana AtFKBP42 that is membrane-bound and interacts with Hsp90. Kamphausen, T., Fanghänel, J., Neumann, D., Schulz, B., Rahfeld, J.U. Plant J. (2002) [Pubmed]
  8. Structural comparison of oxidized and reduced FKBP13 from Arabidopsis thaliana. Gopalan, G., He, Z., Battaile, K.P., Luan, S., Swaminathan, K. Proteins (2006) [Pubmed]
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