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Gene Review:

AT2G41410 - putative calcium-binding protein CML35

Arabidopsis thaliana

Synonyms: F13H10.4, F13H10_4

Jarrett, H.W. et al., Yamaguchi, T. et al., Lee, D. et al., McCurdy, D.W. et al., Harper, J.F. et al., et al.

Xing, Wang, Malik, Miki,

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Disease relevance of AT2G41410

Characterization of an Arabidopsis calmodulin-like domain protein kinase purified from Escherichia coli using an affinity sandwich technique [1].
Calmodulin-like proteins from Arabidopsis and tomato are involved in host defense against Pseudomonas syringae pv. tomato [2].

High impact information on AT2G41410

Taken together, the presence of a vacuolar calmodulin-like protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca(2+)- pH-dependent manner suggests the presence of signaling entities acting within the vacuole [3].
One prediction based upon this model is that calmodulin-activated enzymes would contain a calmodulin-like binding site which, among other attributes, would bind the peptide melittin [4].
Calmodulin-binding proteins also have a calmodulin-like binding site within their structure. The flip-flop model [4].
Activation of an alfalfa cyclin-dependent kinase inhibitor by calmodulin-like domain protein kinase [5].
The 50-member calmodulin-like (CML) Arabidopsis (Arabidopsis thaliana) family encodes proteins containing the predicted Ca(2+)-binding EF-hand motif [6].

Biological context of AT2G41410

These enzymes have a unique structure consisting of a protein kinase catalytic domain fused to carboxy-terminal autoregulatory and calmodulin-like domains [7].
Preceding the tandem repeats at the amino terminus of AtFim1 is a single-EF-hand-like domain with moderate homology to calmodulin-like calcium-binding proteins [8].
Ectopic expression of an Arabidopsis calmodulin-like domain protein kinase-enhanced NADPH oxidase activity and oxidative burst in tomato protoplasts [9].

Associations of AT2G41410 with chemical compounds

A truncation which deletes the calmodulin-like domain, as in mutant delta C-6H, disrupts Ca2+ activation and leaves the enzyme with a basal level of activity [10].

Analytical, diagnostic and therapeutic context of AT2G41410

Microarrays and quantitative RT-PCR were conducted to identify genes and analyze behaviors of calmodulin-like (CML) and xyloglucan endotransglucosylase/hydrolase (XTH) genes [11].

References

Characterization of an Arabidopsis calmodulin-like domain protein kinase purified from Escherichia coli using an affinity sandwich technique. Binder, B.M., Harper, J.F., Sussman, M.R. Biochemistry (1994) [Pubmed]
Calmodulin-like proteins from Arabidopsis and tomato are involved in host defense against Pseudomonas syringae pv. tomato. Chiasson, D., Ekengren, S.K., Martin, G.B., Dobney, S.L., Snedden, W.A. Plant Mol. Biol. (2005) [Pubmed]
Vacuolar Na+/H+ antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca2+- and pH-dependent manner. Yamaguchi, T., Aharon, G.S., Sottosanto, J.B., Blumwald, E. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
Calmodulin-binding proteins also have a calmodulin-like binding site within their structure. The flip-flop model. Jarrett, H.W., Madhavan, R. J. Biol. Chem. (1991) [Pubmed]
Activation of an alfalfa cyclin-dependent kinase inhibitor by calmodulin-like domain protein kinase. Pettkó-Szandtner, A., Mészáros, T., Horváth, G.V., Bakó, L., Csordás-Tóth, E., Blastyák, A., Zhiponova, M., Miskolczi, P., Dudits, D. Plant J. (2006) [Pubmed]
CML24, regulated in expression by diverse stimuli, encodes a potential Ca2+ sensor that functions in responses to abscisic acid, daylength, and ion stress. Delk, N.A., Johnson, K.A., Chowdhury, N.I., Braam, J. Plant Physiol. (2005) [Pubmed]
Characterization of eight new members of the calmodulin-like domain protein kinase gene family from Arabidopsis thaliana. Hrabak, E.M., Dickmann, L.J., Satterlee, J.S., Sussman, M.R. Plant Mol. Biol. (1996) [Pubmed]
Molecular cloning of a novel fimbrin-like cDNA from Arabidopsis thaliana. McCurdy, D.W., Kim, M. Plant Mol. Biol. (1998) [Pubmed]
Ectopic expression of an Arabidopsis calmodulin-like domain protein kinase-enhanced NADPH oxidase activity and oxidative burst in tomato protoplasts. Xing, T., Wang, X.J., Malik, K., Miki, B.L. Mol. Plant Microbe Interact. (2001) [Pubmed]
Genetic identification of an autoinhibitor in CDPK, a protein kinase with a calmodulin-like domain. Harper, J.F., Huang, J.F., Lloyd, S.J. Biochemistry (1994) [Pubmed]
Genome-wide identification of touch- and darkness-regulated Arabidopsis genes: a focus on calmodulin-like and XTH genes. Lee, D., Polisensky, D.H., Braam, J. New Phytol. (2005) [Pubmed]

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