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Gene Review

SKOR  -  potassium channel SKOR

Arabidopsis thaliana

Synonyms: F13E7.21, F13E7_21, STELAR K+ outward rectifier
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Disease relevance of SKOR

  • SKOR expression is strongly inhibited by the stress phytohormone abscisic acid, supporting the hypothesis that control of K+ translocation toward the shoots is part of the plant response to water stress [1].

High impact information on SKOR

  • Expression in Xenopus oocytes identified SKOR as the first member of the Shaker family in plants to be endowed with outwardly rectifying properties [1].
  • SKOR expression is localized in root stelar tissues [1].
  • Activation by K+ did not affect the kinetics of voltage dependence in SKOR, indicating that a voltage-independent gating mechanism underlies the K+ sensing process [2].
  • The physiological interactions between these two ions was investigated by examining aspects of K(+) nutrition in the Arabidopsis salt overly sensitive (sos) mutants, and salt sensitivity in the K(+) transport mutants akt1 (Arabidopsis K(+) transporter) and skor (shaker-like K(+) outward-rectifying channel) [3].
  • SKOR and GORK are outward-rectifying plant potassium channels from Arabidopsis thaliana [4].

Biological context of SKOR


Other interactions of SKOR

  • Three members of the so-called Shaker K+ channel gene family (nine genes identified in Arabidopsis) play a role in these transports: AKT1, SKOR and AKT2 [6].
  • We demonstrate that SKOR and GORK physically interact and assemble into heteromeric K(out) channels [4].
  • Deletion mutants and chimeric proteins generated from SKOR and the K(in) channel alpha-subunit KAT1 revealed that the cytoplasmic C-terminus of SKOR determines channel assembly [4].

Analytical, diagnostic and therapeutic context of SKOR


  1. Identification and disruption of a plant shaker-like outward channel involved in K+ release into the xylem sap. Gaymard, F., Pilot, G., Lacombe, B., Bouchez, D., Bruneau, D., Boucherez, J., Michaux-Ferrière, N., Thibaud, J.B., Sentenac, H. Cell (1998) [Pubmed]
  2. Intracellular K+ sensing of SKOR, a Shaker-type K+ channel from Arabidopsis. Liu, K., Li, L., Luan, S. Plant J. (2006) [Pubmed]
  3. Protection of plasma membrane K+ transport by the salt overly sensitive1 Na+-H+ antiporter during salinity stress. Qi, Z., Spalding, E.P. Plant Physiol. (2004) [Pubmed]
  4. Assembly of plant Shaker-like K(out) channels requires two distinct sites of the channel alpha-subunit. Dreyer, I., Porée, F., Schneider, A., Mittelstädt, J., Bertl, A., Sentenac, H., Thibaud, J.B., Mueller-Roeber, B. Biophys. J. (2004) [Pubmed]
  5. Genes for calcium-permeable channels in the plasma membrane of plant root cells. White, P.J., Bowen, H.C., Demidchik, V., Nichols, C., Davies, J.M. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Regulated expression of Arabidopsis shaker K+ channel genes involved in K+ uptake and distribution in the plant. Pilot, G., Gaymard, F., Mouline, K., Chérel, I., Sentenac, H. Plant Mol. Biol. (2003) [Pubmed]
  7. External K+ modulates the activity of the Arabidopsis potassium channel SKOR via an unusual mechanism. Johansson, I., Wulfetange, K., Porée, F., Michard, E., Gajdanowicz, P., Lacombe, B., Sentenac, H., Thibaud, J.B., Mueller-Roeber, B., Blatt, M.R., Dreyer, I. Plant J. (2006) [Pubmed]
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