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Gene Review

COL2  -  zinc finger protein CONSTANS-LIKE 2

Arabidopsis thaliana

Synonyms: ATCOL2, B-box domain protein 3, BBX3, CONSTANS-LIKE 2, CONSTANS-like 2, ...
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High impact information on COL2

  • Expression of the rice orthologue of the Arabidopsis CONSTANS (CO) gene was increased in the transgenic rice, whereas expression of the rice orthologue of FLOWERING LOCUS T (FT) was suppressed [1].
  • The CCT (for CONSTANS, CONSTANS-LIKE, TOC1) domain is found in 45 Arabidopsis thaliana proteins involved in processes such as photoperiodic flowering, light signaling, and regulation of circadian rhythms [2].
  • They were highly similar to each other and to Hd1, and in addition harbored two conserved regions: two zinc finger motifs and CONSTANS, CONSTANS-LIKE and TIMING OF CAB EXPRESSION 1 (CCT) domain like CO/Hd1 [3].
  • CONSTANS, the first isolated member, is a putative zinc finger transcription factor that promotes the induction of flowering in A. thaliana in long photoperiods [4].
  • The rate of evolution of COL genes seems to have accelerated during later stages of evolution, possibly as an effect of frequent gene duplications [4].

Biological context of COL2


Regulatory relationships of COL2

  • TSF expression was induced rapidly upon activation of CONSTANS (CO) [7].

Other interactions of COL2


  1. Adaptation of photoperiodic control pathways produces short-day flowering in rice. Hayama, R., Yokoi, S., Tamaki, S., Yano, M., Shimamoto, K. Nature (2003) [Pubmed]
  2. CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis. Wenkel, S., Turck, F., Singer, K., Gissot, L., Le Gourrierec, J., Samach, A., Coupland, G. Plant Cell (2006) [Pubmed]
  3. Characterization and functional analysis of three wheat genes with homology to the CONSTANS flowering time gene in transgenic rice. Nemoto, Y., Kisaka, M., Fuse, T., Yano, M., Ogihara, Y. Plant J. (2003) [Pubmed]
  4. Rapid evolution of the family of CONSTANS LIKE genes in plants. Lagercrantz, U., Axelsson, T. Mol. Biol. Evol. (2000) [Pubmed]
  5. Molecular cloning and expression analysis of a CONSTANS homologue, PnCOL1, from Pharbitis nil. Kim, S.J., Moon, J., Lee, I., Maeng, J., Kim, S.R. J. Exp. Bot. (2003) [Pubmed]
  6. Nitric oxide represses the Arabidopsis floral transition. He, Y., Tang, R.H., Hao, Y., Stevens, R.D., Cook, C.W., Ahn, S.M., Jing, L., Yang, Z., Chen, L., Guo, F., Fiorani, F., Jackson, R.B., Crawford, N.M., Pei, Z.M. Science (2004) [Pubmed]
  7. TWIN SISTER OF FT (TSF) acts as a floral pathway integrator redundantly with FT. Yamaguchi, A., Kobayashi, Y., Goto, K., Abe, M., Araki, T. Plant Cell Physiol. (2005) [Pubmed]
  8. Analysis of the function of two circadian-regulated CONSTANS-LIKE genes. Ledger, S., Strayer, C., Ashton, F., Kay, S.A., Putterill, J. Plant J. (2001) [Pubmed]
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