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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ROF1  -  rotamase FKBP 1

Arabidopsis thaliana

Synonyms: ATFKBP62, FK506 BINDING PROTEIN 62, FKBP62
 
 
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Disease relevance of ROF1

  • Although ROF1 and ROF2 share 85% identity, their expression in response to heat stress is differentially regulated [1].
 

High impact information on ROF1

  • Exposure of plants to low levels of MDA using a recently developed protocol powerfully upregulated many genes on a cDNA microarray with a bias towards those implicated in abiotic/environmental stress (e.g. ROF1 and XERO2) [2].
  • Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90 [1].
  • Transgenic plants expressing ROF1 promoter fused to GUS reporter gene reveal that ROF1 expression is organ specific [1].
  • These two enzymes are responsible for PPIase activity in both soluble and membrane-associated fractions of thylakoid lumen suggesting that other lumenal immunophilins are not active towards the peptide substrates [3].
  • Profound redox-dependence of PPIase activity implies oxidative activation of protein folding catalysis under oxidative stress and photosynthetic oxygen production in the thylakoid lumen of plant chloroplasts [3].
 

Biological context of ROF1

References

  1. Arabidopsis immunophilins ROF1 (AtFKBP62) and ROF2 (AtFKBP65) exhibit tissue specificity, are heat-stress induced, and bind HSP90. Aviezer-Hagai, K., Skovorodnikova, J., Galigniana, M., Farchi-Pisanty, O., Maayan, E., Bocovza, S., Efrat, Y., von Koskull-D??ring, P., Ohad, N., Breiman, A. Plant Mol. Biol. (2007) [Pubmed]
  2. Selective and powerful stress gene expression in Arabidopsis in response to malondialdehyde. Weber, H., Chételat, A., Reymond, P., Farmer, E.E. Plant J. (2004) [Pubmed]
  3. Profound redox sensitivity of peptidyl-prolyl isomerase activity in Arabidopsis thylakoid lumen. Shapiguzov, A., Edvardsson, A., Vener, A.V. FEBS Lett. (2006) [Pubmed]
  4. Novel structure of a high molecular weight FK506 binding protein from Arabidopsis thaliana. Vucich, V.A., Gasser, C.S. Mol. Gen. Genet. (1996) [Pubmed]
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