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Gene Review

Fkbp4  -  FK506 binding protein 4

Rattus norvegicus

Synonyms: 52 kDa FK506-binding protein, 52 kDa FKBP, 59 kDa immunophilin, FK506-binding protein 4, FKBP-4, ...
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Disease relevance of Fkbp4

  • We determined the hemoglobin binding index (HBI) [(mmol compound/mol Hb)/(mmol compound/kg body weight)] of several nitroarenes in female Wistar rats [1].

High impact information on Fkbp4


Biological context of Fkbp4

  • In the present study, we demonstrate using specific enzyme inhibitors and antisense oligonucleotides that both JAK2 and p59 Fyn tyrosine kinases are required for the Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT1 in VSMCs [6].
  • FKBP59 also includes in its structure a tetratricopeptide repeat (TPR) motif and could have a function in the cell division process [5].
  • Increasing levels of FKBP59 mRNA became obvious from the midpachytene stage, and the strongest signal was observed in the late pachytene, diplotene, and diakinesis primary spermatocytes [5].
  • During prepubertal development, Northern blot and in situ hybridization of rat testes examined at various postnatal ages revealed that FKBP59 mRNA was not expressed at over a basal level until the pachytene stage [5].

Anatomical context of Fkbp4

  • All three MAbs specifically recognized the p59 and p56 isoforms of Hck in transiently transfected 293T cells and in a murine macrophage cell line [7].

Associations of Fkbp4 with chemical compounds

  • The search for the corresponding effector genes revealed that the expression of FKBP25, FKBP38 and FKBP52 (analysis by reverse transcription-polymerase chain reaction (RT-PCR) did not change following H(2)O(2) or FK506, and this was also true for the expression of apoptosis-related genes caspase 3, bax, bcl-2 and bcl-xL (analysis by Multiplex-PCR) [8].
  • The HBI of diepoxybutane (about 8) for epoxybutanediol adduct formation is approximately the same as that of epoxybutanediol itself [9].
  • Haemoglobin binding indexes, HBI, (pmol adduct/g per mumol of alkylating agent, or, for butadiene, per ppm x h), were calculated [9].
  • The HBI for epoxybutanediol (about 10) is comparable to that of ethylene oxide in the rat demonstrating a similar capacity of the two compounds to alkylate nucleophilic sites in vivo [9].
  • Progesterone, alone, caused a decrease in p37, p59, and a slight increase in p40 [10].

Analytical, diagnostic and therapeutic context of Fkbp4


  1. Hemoglobin binding of nitroarenes and quantitative structure-activity relationships. Sabbioni, G. Chem. Res. Toxicol. (1994) [Pubmed]
  2. Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. Liang, H., Venema, V.J., Wang, X., Ju, H., Venema, R.C., Marrero, M.B. J. Biol. Chem. (1999) [Pubmed]
  3. The effect of cyclosporine administration on the cellular distribution and content of cyclophilin. McDonald, M.L., Ardito, T., Marks, W.H., Kashgarian, M., Lorber, M.I. Transplantation (1992) [Pubmed]
  4. Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046. Li, F., Omori, N., Hayashi, T., Jin, G., Sato, K., Nagano, I., Shoji, M., Abe, K. J. Neurosci. Res. (2004) [Pubmed]
  5. Stage-specific expression of the immunophilin FKBP59 messenger ribonucleic acid and protein during differentiation of male germ cells in rabbits and rats. Sananes, N., Baulieu, E.E., Le Goascogne, C. Biol. Reprod. (1998) [Pubmed]
  6. Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by Janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1. Venema, R.C., Venema, V.J., Eaton, D.C., Marrero, M.B. J. Biol. Chem. (1998) [Pubmed]
  7. Generation and characterization of monoclonal antibodies to the Src-family kinase Hck. Cartledge, K., Dunn, A.R., Scholz, G. Hybridoma (2000) [Pubmed]
  8. The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin. Klettner, A., Baumgrass, R., Zhang, Y., Fischer, G., Bürger, E., Herdegen, T., Mielke, K. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  9. Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides. Pérez, H.L., Lähdetie, J., Landin, H., Kilpeläinen, I., Koivisto, P., Peltonen, K., Osterman-Golkar, S. Chem. Biol. Interact. (1997) [Pubmed]
  10. Steroidal regulation of rat uterine in vitro mRNA translation products. Komm, B.S., Lyttle, C.R. J. Steroid Biochem. (1984) [Pubmed]
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