Disease relevance of Fkbp4

• We determined the hemoglobin binding index (HBI) [(mmol compound/mol Hb)/(mmol compound/kg body weight)] of several nitroarenes in female Wistar rats [1].

High impact information on Fkbp4

• We have shown previously that the JAK2 tyrosine kinase and the Src family p59 Fyn tyrosine kinase are required for Ang II-induced STAT1 tyrosine phosphorylation in VSMCs [2].
• Cyclophilin (CYP), an intracellular protein sharing amino acid sequence identity with the enzyme peptidyl-prolyl cis-trans isomerase has become the leading candidate for the receptor responsible for cyclosporine biological effects [3].
• Immunoreactivity and the number of cells stained positively for FKBP12, FKBP52, caspase-8, cytochrome c, and caspase-3 were also reduced markedly in the brain after GPI-1046 treatment [4].
• High expression of FKBP59 mRNA did not occur in earlier and later germ cell stages [5].
• In situ hybridization experiments revealed an overexpression of FKBP59 mRNA in rabbit and rat testes in comparison with other organs [5].

Biological context of Fkbp4

• In the present study, we demonstrate using specific enzyme inhibitors and antisense oligonucleotides that both JAK2 and p59 Fyn tyrosine kinases are required for the Ang II-induced tyrosine phosphorylation and nuclear translocation of STAT1 in VSMCs [6].
• FKBP59 also includes in its structure a tetratricopeptide repeat (TPR) motif and could have a function in the cell division process [5].
• Increasing levels of FKBP59 mRNA became obvious from the midpachytene stage, and the strongest signal was observed in the late pachytene, diplotene, and diakinesis primary spermatocytes [5].
• During prepubertal development, Northern blot and in situ hybridization of rat testes examined at various postnatal ages revealed that FKBP59 mRNA was not expressed at over a basal level until the pachytene stage [5].

Anatomical context of Fkbp4

• All three MAbs specifically recognized the p59 and p56 isoforms of Hck in transiently transfected 293T cells and in a murine macrophage cell line [7].

Associations of Fkbp4 with chemical compounds

• The search for the corresponding effector genes revealed that the expression of FKBP25, FKBP38 and FKBP52 (analysis by reverse transcription-polymerase chain reaction (RT-PCR) did not change following H(2)O(2) or FK506, and this was also true for the expression of apoptosis-related genes caspase 3, bax, bcl-2 and bcl-xL (analysis by Multiplex-PCR) [8].
• The HBI of diepoxybutane (about 8) for epoxybutanediol adduct formation is approximately the same as that of epoxybutanediol itself [9].
• Haemoglobin binding indexes, HBI, (pmol adduct/g per mumol of alkylating agent, or, for butadiene, per ppm x h), were calculated [9].
• The HBI for epoxybutanediol (about 10) is comparable to that of ethylene oxide in the rat demonstrating a similar capacity of the two compounds to alkylate nucleophilic sites in vivo [9].
• Progesterone, alone, caused a decrease in p37, p59, and a slight increase in p40 [10].

Analytical, diagnostic and therapeutic context of Fkbp4

• High expression of the FKBP59 protein was demonstrated in the rabbit testis by Western blot and was localized by immunohistochemistry from late pachytene spermatocytes to round spermatids [5].

References