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Gene Review

CESA1  -  cellulose synthase A catalytic subunit 1...

Arabidopsis thaliana

Synonyms: ANY1, AtCESA1, CELLULOSE SYNTHASE 1, F8B4.110, F8B4_110, ...
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High impact information on CESA1


Biological context of CESA1

  • The embryonic phenotype of the presumed rsw1 null mutant indicates that the RSW1(CESA1) product has a critical, nonredundant function, but is nevertheless not strictly required for primary cell wall formation [5].
  • Assessing the function of individual CESA genes will require the identification of the null-mutant phenotypes and of the gene expression profiles for each gene [5].
  • We further identified two new mutations in the RADIALLY SWOLLEN1 (RSW1/CESA1) gene of Arabidopsis that obstruct organized growth in both shoot and root and interfere with cell division and cell expansion already in embryogenesis [5].
  • The rsw1 mutant of Arabidopsis thaliana has a single amino acid substitution in a putative glycosyl transferase that causes a temperature-dependent reduction in cellulose production [6].

Anatomical context of CESA1

  • Inhibition of microtubule polymerization changed the fine-scale distribution and pattern of moving CESA complexes in the membrane, indicating a relatively direct mechanism for guidance of cellulose deposition by the cytoskeleton [7].

Associations of CESA1 with chemical compounds

  • The shoots of rsw2-1 seedlings produce less cellulose and accumulate a short chain, readily extractable glucan resembling that reported for rsw1 (which is defective in a putative glycosyltransferase required for cellulose synthesis) [8].
  • Furthermore, in contrast to radial swelling1 (rsw1) plants, irx3 plants show no increase in the accumulation of beta-1,4-linked glucose in the noncrystalline cell wall fraction [9].
  • This is consistent with rsw3 reducing glycoprotein delivery from the ER to the plasma membrane whereas rsw1 and rsw2 act more rapidly by affecting the properties of already delivered enzymes [10].

Other interactions of CESA1

  • The Rsw2(-) phenotype generally resembles the Kor(-) and cellulose-deficient Rsw1(-) phenotypes, but anther dehiscence is impaired in Rsw2-1(-) [8].
  • The limited changes seen in the monosaccharide compositions, glycosidic linkage patterns and quantities of non-cellulosic polysaccharides support the view that the RSW1, RSW2 and RSW3 genes are specifically involved in cellulose synthesis [11].
  • The products of the cellulose synthase A (CESA) gene family are thought to function as isoforms of the cellulose synthase catalytic subunit, but for most CESA genes, the exact role in plant growth is still unknown [5].
  • Because RSW1 was previously shown to encode a catalytic subunit of cellulose synthase, the similar morphology of knf and rsw1-2 embryos suggests that the radially swollen phenotype of knf mutants is largely due to their cellulose deficiency [3].

Analytical, diagnostic and therapeutic context of CESA1


  1. Cellulose synthesis in higher plants. Somerville, C. Annu. Rev. Cell Dev. Biol. (2006) [Pubmed]
  2. Molecular analysis of cellulose biosynthesis in Arabidopsis. Arioli, T., Peng, L., Betzner, A.S., Burn, J., Wittke, W., Herth, W., Camilleri, C., Höfte, H., Plazinski, J., Birch, R., Cork, A., Glover, J., Redmond, J., Williamson, R.E. Science (1998) [Pubmed]
  3. Alpha-glucosidase I is required for cellulose biosynthesis and morphogenesis in Arabidopsis. Gillmor, C.S., Poindexter, P., Lorieau, J., Palcic, M.M., Somerville, C. J. Cell Biol. (2002) [Pubmed]
  4. The Arabidopsis mutant cev1 links cell wall signaling to jasmonate and ethylene responses. Ellis, C., Karafyllidis, I., Wasternack, C., Turner, J.G. Plant Cell (2002) [Pubmed]
  5. Genetic complexity of cellulose synthase a gene function in Arabidopsis embryogenesis. Beeckman, T., Przemeck, G.K., Stamatiou, G., Lau, R., Terryn, N., De Rycke, R., Inzé, D., Berleth, T. Plant Physiol. (2002) [Pubmed]
  6. Wall architecture in the cellulose-deficient rsw1 mutant of Arabidopsis thaliana: microfibrils but not microtubules lose their transverse alignment before microfibrils become unrecognizable in the mitotic and elongation zones of roots. Sugimoto, K., Williamson, R.E., Wasteneys, G.O. Protoplasma (2001) [Pubmed]
  7. Visualization of cellulose synthase demonstrates functional association with microtubules. Paredez, A.R., Somerville, C.R., Ehrhardt, D.W. Science (2006) [Pubmed]
  8. Temperature-sensitive alleles of RSW2 link the KORRIGAN endo-1,4-beta-glucanase to cellulose synthesis and cytokinesis in Arabidopsis. Lane, D.R., Wiedemeier, A., Peng, L., Höfte, H., Vernhettes, S., Desprez, T., Hocart, C.H., Birch, R.J., Baskin, T.I., Burn, J.E., Arioli, T., Betzner, A.S., Williamson, R.E. Plant Physiol. (2001) [Pubmed]
  9. The irregular xylem3 locus of Arabidopsis encodes a cellulose synthase required for secondary cell wall synthesis. Taylor, N.G., Scheible, W.R., Cutler, S., Somerville, C.R., Turner, S.R. Plant Cell (1999) [Pubmed]
  10. The cellulose-deficient Arabidopsis mutant rsw3 is defective in a gene encoding a putative glucosidase II, an enzyme processing N-glycans during ER quality control. Burn, J.E., Hurley, U.A., Birch, R.J., Arioli, T., Cork, A., Williamson, R.E. Plant J. (2002) [Pubmed]
  11. Fractionation of carbohydrates in Arabidopsis root cell walls shows that three radial swelling loci are specifically involved in cellulose production. Peng, L., Hocart, C.H., Redmond, J.W., Williamson, R.E. Planta (2000) [Pubmed]
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