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Gene Review

PAI2  -  phosphoribosylanthranilate isomerase 2

Arabidopsis thaliana

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High impact information on PAI2

  • Revertant lines display coordinately reduced methylation of both PAI2 and PAI3, implying that this hypomethylation acts in a concerted manner across the genome rather than at individual sites [1].
  • The progressive loss of fluorescence correlated with a progressive loss of methylation from the PAI2 gene [2].
  • In order to elucidate the factors that control genomic DNA methylation patterning, a genetic screen for mutations that disrupt methylation-correlated silencing of the endogenous gene PAI2 was conducted in Arabidopsis: This screen yielded seven loss-of-function alleles in a SET domain protein with histone H3 Lys9 methyltransferase activity, SUVH4 [3].
  • DNA sequence analysis of cDNA and genomic clones indicated that the PAI1 and PAI2 [4].
  • Yeast artificial chromosome hybridization studies indicated that the PAI2 gene is tightly linked to the anthranilate synthase alpha subunit 1 (ASA1) gene on chromosome 5 [4].

Biological context of PAI2


Associations of PAI2 with chemical compounds

  • The mutations conferred reduced cytosine methylation on PAI2, especially in non-CG sequence contexts, but did not affect methylation on another PAI locus carrying two genes arranged as an inverted repeat [3].
  • Previous analysis of the PAI tryptophan biosynthetic gene family in Arabidopsis thaliana revealed that the Wassilewskija (WS) ecotype has four PAI genes at three unlinked sites: a tail-to-tail inverted repeat at one locus (PAI1-PAI4) plus singlet genes at two other loci (PAI2 and PAI3) [7].

Other interactions of PAI2

  • The extreme nucleotide conservation between the unlinked PAI1 and PAI2 loci suggests that this gene family is actively evolving [4].
  • Both PAI1 and PAI3 showed approximately 10-fold stronger expression than PAI2 [8].


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