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Gene Review

ASA1  -  anthranilate synthase component I-1

Arabidopsis thaliana

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High impact information on ASA1


Biological context of ASA1


Associations of ASA1 with chemical compounds

  • Together, these findings reveal that ASA1 and ASB1 are key elements in the regulation of auxin production and an unexpected node of interaction between ethylene responses and auxin biosynthesis in Arabidopsis [1].
  • Concurrently, tryptamine levels increase up to 9-fold in the induced trp5:ASB1 line (specific yield ca. 1.9 mg g(-1) dry weight) as compared with only a 4-fold tryptamine increase in the induced trp5 line (specific yield ca. 0.3 mg g(-1) dry weight) [7].
  • Metabolic changes in transgenic Arabidopsis plants expressing the feedback-resistant anthranilate synthase alpha subunit gene OASA1D were investigated with respect to Trp synthesis and effects on secondary metabolism [8].
  • In an attempt to more successfully engineer the indole pathway, a wild type Arabidopsis ASbeta subunit (ASB1) cDNA was constitutively expressed along with the inducible expression of trp5 and TDC in C. roseus hairy roots [7].

Regulatory relationships of ASA1


Other interactions of ASA1


  1. A Link between ethylene and auxin uncovered by the characterization of two root-specific ethylene-insensitive mutants in Arabidopsis. Stepanova, A.N., Hoyt, J.M., Hamilton, A.A., Alonso, J.M. Plant Cell (2005) [Pubmed]
  2. Two anthranilate synthase genes in Arabidopsis: defense-related regulation of the tryptophan pathway. Niyogi, K.K., Fink, G.R. Plant Cell (1992) [Pubmed]
  3. Characterization of rice anthranilate synthase alpha-subunit genes OASA1 and OASA2. Tryptophan accumulation in transgenic rice expressing a feedback-insensitive mutant of OASA1. Tozawa, Y., Hasegawa, H., Terakawa, T., Wakasa, K. Plant Physiol. (2001) [Pubmed]
  4. Molecular basis of alpha-methyltryptophan resistance in amt-1, a mutant of Arabidopsis thaliana with altered tryptophan metabolism. Kreps, J.A., Ponappa, T., Dong, W., Town, C.D. Plant Physiol. (1996) [Pubmed]
  5. Mutations in Arabidopsis thaliana genes involved in the tryptophan biosynthesis pathway affect root waving on tilted agar surfaces. Rutherford, R., Gallois, P., Masson, P.H. Plant J. (1998) [Pubmed]
  6. Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels. Hughes, E.H., Hong, S.B., Gibson, S.I., Shanks, J.V., San, K.Y. Biotechnol. Bioeng. (2004) [Pubmed]
  7. Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots. Hong, S.B., Peebles, C.A., Shanks, J.V., San, K.Y., Gibson, S.I. J. Biotechnol. (2006) [Pubmed]
  8. Metabolic changes in Arabidopsis thaliana expressing the feedback-resistant anthranilate synthase alpha subunit gene OASA1D. Ishihara, A., Asada, Y., Takahashi, Y., Yabe, N., Komeda, Y., Nishioka, T., Miyagawa, H., Wakasa, K. Phytochemistry (2006) [Pubmed]
  9. Transient effects of overexpressing anthranilate synthase alpha and beta subunits in Catharanthus roseus hairy roots. Peebles, C.A., Hong, S.B., Gibson, S.I., Shanks, J.V., San, K.Y. Biotechnol. Prog. (2005) [Pubmed]
  10. 5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana. Barczak, A.J., Zhao, J., Pruitt, K.D., Last, R.L. Genetics (1995) [Pubmed]
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