High impact information on AT5G06290

• Vitamin E is considered a major antioxidant in biomembranes, but little evidence exists for this function in plants under photooxidative stress [1].
• Vitamin B6 is an essential coenzyme for numerous metabolic enzymes and is a potent antioxidant [2].
• Most studies on the function of tocopherols in plants have focused on their photo-protective and antioxidant properties, and it has been recently suggested, though not yet demonstrated, that they may also play a role in cellular signaling [3].
• The best-characterized member of the chloroplast peroxiredoxins is 2-Cys Prx that is associated with the stroma side of the thylakoid membrane and is considered to participate in antioxidant defense and protection of photosynthesis [4].
• The Arabidopsis ascorbate peroxidase 3 is a peroxisomal membrane-bound antioxidant enzyme and is dispensable for Arabidopsis growth and development [5].

Biological context of AT5G06290

• Copper-induced oxidative stress and antioxidant defence in Arabidopsis thaliana [6].

Associations of AT5G06290 with chemical compounds

• Content of reactive oxygen species (ROS): O2*-, H2O2 and OH* as well as activities of antioxidant enzymes: superoxide dismutase (SOD), guaiacol peroxidase (POX) and catalase (CAT) were studied in leaves of Arabidopsis thaliana ecotype Columbia, treated with Cu excess (0, 5, 25, 30, 50, 75, 100, 150 and 300 microM) [6].

Analytical, diagnostic and therapeutic context of AT5G06290

• Taken together, the results demonstrate an antioxidant role for plant oxy5 gene in mammalian cells, which can be potentially utilized in gene therapy programs aimed at reducing the deleterious effects of ROS [7].

References