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Gene Review

PRDX2  -  peroxiredoxin 2

Homo sapiens

Synonyms: HEL-S-2a, MGC4104, NKEF-B, NKEFB, Natural killer cell-enhancing factor B, ...
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Disease relevance of PRDX2


Psychiatry related information on PRDX2

  • Two-hundred and seventy-one 11- and 12-year-olds, with elevated depressive symptoms, were randomized to PRP or usual care [5].
  • Most importantly we found that in addition to increased abnormalities with increasing substance use disorder the PI/SD group had significantly more abnormalities compared to the PI group with regard to both the TSA (P < .05) and AVBIT (P < .05) composite parameters as meas[6]
  • PRP did not significantly prevent depressive disorders but significantly prevented depression, anxiety, and adjustment disorders (when combined) among high-symptom participants [5].
  • METHODS: Pain thresholds were examined with a psychophysical computerized quantitative thermal sensory testing device (TSA 2001) in healthy volunteers recruited from three different Asian ethnic groups [7].

High impact information on PRDX2

  • As shown by mobility-shift, methylation interference, and mutational analyses, the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP; however, the two proteins differ in molecular weight [8].
  • Thus, immunoselection mediated by T lymphocytes during metastasis formation could be directed against both MHC and TSA antigens [9].
  • Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C [10].
  • Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes [3].
  • A cDNA corresponding to a thiol-specific antioxidant enzyme (TSA) was isolated from a rat brain cDNA library with the use of antibodies to bovine TSA [3].

Chemical compound and disease context of PRDX2


Biological context of PRDX2


Anatomical context of PRDX2


Associations of PRDX2 with chemical compounds

  • In contrast to TPx, in which one of the two conserved cysteines is oxidized to Cys-SOH and then immediately reacts with the second conserved cysteine of the second subunit of the enzyme homodimer to form an intermolecular disulfide, the Cys-SOH of 1-Cys Prx does not form a disulfide [22].
  • The thiol specificity of the protective activity of TSA derives from the fact that the oxidized form of TSA can be converted back to its sulfhydryl form by treatment with thiols but not by ascorbate [23].
  • The thiol-specific antioxidant protein (TSA) protects glutamine synthetase from inactivation by a metal-catalyzed oxidation (MCO) system comprised of dithiothreitol (DTT)/Fe3+/O2 but not by the ascorbate/Fe3+/O2 MCO system [23].
  • Like catalase, TSA prevents the initiation of the rapid O2 uptake phase during MCO of DTT but causes only partial inhibition when added after the reaction is well into the propagation phase [23].
  • Reduced thioredoxin serves as an electron donor for thioredoxin peroxidase (TPx) which consequently reduces H(2)O(2) to H(2)O [24].
  • These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents [25].

Regulatory relationships of PRDX2


Other interactions of PRDX2


Analytical, diagnostic and therapeutic context of PRDX2


  1. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. Sánchez-Font, M.F., Sebastià, J., Sanfeliu, C., Cristòfol, R., Marfany, G., Gonzàlez-Duarte, R. Cell. Mol. Life Sci. (2003) [Pubmed]
  2. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. Knoops, B., Clippe, A., Bogard, C., Arsalane, K., Wattiez, R., Hermans, C., Duconseille, E., Falmagne, P., Bernard, A. J. Biol. Chem. (1999) [Pubmed]
  3. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Chae, H.Z., Robison, K., Poole, L.B., Church, G., Storz, G., Rhee, S.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. Geiben-Lynn, R., Kursar, M., Brown, N.V., Addo, M.M., Shau, H., Lieberman, J., Luster, A.D., Walker, B.D. J. Biol. Chem. (2003) [Pubmed]
  5. Preventing depression among early adolescents in the primary care setting: a randomized controlled study of the Penn Resiliency Program. Gillham, J.E., Hamilton, J., Freres, D.R., Patton, K., Gallop, R. Journal of abnormal child psychology. (2006) [Pubmed]
  6. Substance use disorder exacerbates brain electrophysiological abnormalities in a psychiatrically-ill population. Braverman, E.R., Blum, K. Clinical EEG (electroencephalography). (1996) [Pubmed]
  7. Do ethnicity and gender have an impact on pain thresholds in minor dermatologic procedures? A study on thermal pain perception thresholds in Asian ethinic groups. Yosipovitch, G., Meredith, G., Chan, Y.H., Goh, C.L. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). (2004) [Pubmed]
  8. A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Barberis, A., Widenhorn, K., Vitelli, L., Busslinger, M. Genes Dev. (1990) [Pubmed]
  9. The relationship between MHC antigen expression and metastasis. Gopas, J., Rager-Zisman, B., Bar-Eli, M., Hämmerling, G.J., Segal, S. Adv. Cancer Res. (1989) [Pubmed]
  10. Reduction of 1-Cys peroxiredoxins by ascorbate changes the thiol-specific antioxidant paradigm, revealing another function of vitamin C. Monteiro, G., Horta, B.B., Pimenta, D.C., Augusto, O., Netto, L.E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  11. Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells. Khanim, F.L., Gommersall, L.M., Wood, V.H., Smith, K.L., Montalvo, L., O'Neill, L.P., Xu, Y., Peehl, D.M., Stewart, P.M., Turner, B.M., Campbell, M.J. Oncogene (2004) [Pubmed]
  12. Production of toxic-shock-associated protein(s) in Staphylococcus aureus strains isolated from 1956 through 1982. Hayes, P.S., Graves, L.M., Feeley, J.C., Hancock, G.A., Cohen, M.L., Reingold, A.L., Broome, C.V., Hightower, A.W. J. Clin. Microbiol. (1984) [Pubmed]
  13. One-stage method for assay of tissue factor activity of leukemic cell with special reference to disseminated intravascular coagulation. Andoh, K., Sadakata, H., Uchiyama, T., Narahara, N., Tanaka, H., Kobayashi, N., Maekawa, T. Am. J. Clin. Pathol. (1990) [Pubmed]
  14. Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells. Koyama, N., Koschmieder, S., Tyagi, S., Nürnberger, H., Wagner, S., Böcker, U., Hoelzer, D., Gerhard Ottmann, O., Kalina, U. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Turbulence slope after atrial premature complexes is an independent predictor of mortality in survivors of acute myocardial infarction. Wichterle, D., Camm, A.J., Malik, M. J. Cardiovasc. Electrophysiol. (2004) [Pubmed]
  16. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. Phelan, S.A. Antioxid. Redox Signal. (1999) [Pubmed]
  17. Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. Fatma, N., Singh, D.P., Shinohara, T., Chylack, L.T. J. Biol. Chem. (2001) [Pubmed]
  18. Abrin triggers cell death by inactivating a thiol-specific antioxidant protein. Shih, S.F., Wu, Y.H., Hung, C.H., Yang, H.Y., Lin, J.Y. J. Biol. Chem. (2001) [Pubmed]
  19. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. Pahl, P., Berger, R., Hart, I., Chae, H.Z., Rhee, S.G., Patterson, D. Genomics (1995) [Pubmed]
  20. SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria. Watabe, S., Hiroi, T., Yamamoto, Y., Fujioka, Y., Hasegawa, H., Yago, N., Takahashi, S.Y. Eur. J. Biochem. (1997) [Pubmed]
  21. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution. Declercq, J.P., Evrard, C., Clippe, A., Stricht, D.V., Bernard, A., Knoops, B. J. Mol. Biol. (2001) [Pubmed]
  22. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. Kang, S.W., Baines, I.C., Rhee, S.G. J. Biol. Chem. (1998) [Pubmed]
  23. Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties. TSA possesses thiol peroxidase activity. LES Netto, n.u.l.l., Chae, H.Z., Kang, S.W., Rhee, S.G., Stadtman, E.R. J. Biol. Chem. (1996) [Pubmed]
  24. Thioredoxin reductase - its role in epidermal redox status. Schallreuter, K.U., Wood, J.M. J. Photochem. Photobiol. B, Biol. (2001) [Pubmed]
  25. The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents. Peskin, A.V., Low, F.M., Paton, L.N., Maghzal, G.J., Hampton, M.B., Winterbourn, C.C. J. Biol. Chem. (2007) [Pubmed]
  26. Disease-specific proteins from rheumatoid arthritis patients. Kim, C.W., Cho, E.H., Lee, Y.J., Kim, Y.H., Hah, Y.S., Kim, D.R. J. Korean Med. Sci. (2006) [Pubmed]
  27. Thioredoxin peroxidase (natural killer enhancing factor) regulation of activator protein-1 function in endothelial cells. Shau, H., Huang, A.C., Faris, M., Nazarian, R., de Vellis, J., Chen, W. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  28. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stresses. Shau, H., Kim, A.T., Hedrick, C.C., Lusis, A.J., Tompkins, C., Finney, R., Leung, D.W., Paglia, D.E. Free Radic. Biol. Med. (1997) [Pubmed]
  29. Identification of new proteins in follicular fluid of mature human follicles. Anahory, T., Dechaud, H., Bennes, R., Marin, P., Lamb, N.J., Laoudj, D. Electrophoresis (2002) [Pubmed]
  30. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Rahman, I., Gilmour, P.S., Jimenez, L.A., MacNee, W. Mol. Cell. Biochem. (2002) [Pubmed]
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