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Gene Review

Jafrac1  -  thioredoxin peroxidase 1

Drosophila melanogaster

Synonyms: 1633, CG1633, Cytosolic thioredoxin peroxidase, DPx-4783, DPx4783, ...
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High impact information on Jafrac1


Biological context of Jafrac1

  • The B. mori TPx (BmTPx) cDNA contains an open reading frame of 585 bp encoding 195 amino acid residues and possesses two cysteine residues that are characteristic of 2-Cys subgroup of peroxiredoxin family [5].
  • One of them, Jafrac1, encodes the SSP5111 protein searched, had 194 amino acids and mapped in the region 11E in the X chromosome [4].
  • The eclosion and oviposition rhythms of flies from a population of Drosophila melanogaster maintained under constant conditions of the laboratory were assayed under constant light (LL), constant darkness (DD), and light/dark (LD) cycles of 10:10h (T20), 12:12h (T24), and 14:14h (T28) [6].

Other interactions of Jafrac1


Analytical, diagnostic and therapeutic context of Jafrac1

  • 2D gel electrophoresis followed by microsequencing has been used to purify and identify a protein (catalogued in the database as SSP5111) from Drosophila wing imaginal discs of third instar larvae that showed significant differences in their level of expression when compared with other imaginal discs of the same age [4].
  • Molecular cloning and characterization of a peroxiredoxin gene from the mole cricket, Gryllotalpa orientalis [7].
  • Sequence analysis of an evolutionarily conserved stress-responsive protein, Drosophila Peroxiredoxin I (dPrx I), found the transcript to have two alternative 5'UTRs that lead to an identical coding sequence: namely Ia and Ib [8].


  1. The Thioredoxin Specificity of Drosophila GPx: A Paradigm for a Peroxiredoxin-like Mechanism of many Glutathione Peroxidases. Maiorino, M., Ursini, F., Bosello, V., Toppo, S., Tosatto, S.C., Mauri, P., Becker, K., Roveri, A., Bulato, C., Benazzi, L., De Palma, A., Floh??, L. J. Mol. Biol. (2007) [Pubmed]
  2. A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection. Peterson, T.M., Luckhart, S. Free Radic. Biol. Med. (2006) [Pubmed]
  3. A putative glutathione peroxidase of Drosophila encodes a thioredoxin peroxidase that provides resistance against oxidative stress but fails to complement a lack of catalase activity. Missirlis, F., Rahlfs, S., Dimopoulos, N., Bauer, H., Becker, K., Hilliker, A., Phillips, J.P., Jäckle, H. Biol. Chem. (2003) [Pubmed]
  4. Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila. Rodriguez, J., Agudo, M., Van Damme, J., Vandekerckhove, J., Santarén, J.F. Eur. J. Biochem. (2000) [Pubmed]
  5. Characterization of a silkworm thioredoxin peroxidase that is induced by external temperature stimulus and viral infection. Lee, K.S., Kim, S.R., Park, N.S., Kim, I., Kang, P.D., Sohn, B.H., Choi, K.H., Kang, S.W., Je, Y.H., Lee, S.M., Sohn, H.D., Jin, B.R. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  6. Multi-oscillatory control of eclosion and oviposition rhythms in Drosophila melanogaster: evidence from limits of entrainment studies. Paranjpe, D.A., Anitha, D., Joshi, A., Sharma, V.K. Chronobiol. Int. (2004) [Pubmed]
  7. Molecular cloning and characterization of a peroxiredoxin gene from the mole cricket, Gryllotalpa orientalis. Kim, I., Lee, K.S., Hwang, J.S., Ahn, M.Y., Li, J., Sohn, H.D., Jin, B.R. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  8. Distinct translation regulation by two alternative 5'UTRs of a stress-responsive protein--dPrx I. Chen, C.W., Lin, T.Y., Chen, T.C., Juang, J.L. J. Biomed. Sci. (2005) [Pubmed]
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