High impact information on TFL2

• In contrast, a heterochromatin protein 1 homolog, LHP1, had no effect on PAI methylation [1].
• Our results imply that LHP1 recruitment to chromatin is mediated, at least in part, through interaction with methyl K9 and that LHP1 controls different nuclear processes via transient binding to its nuclear sites [2].
• Mutations in TFL2 derepress FT expression within the vascular tissues of leaves, resulting in daylength-independent early flowering [3].
• No single loss-of-function mutation in the histone methyltransferases studied disrupted the vernalization response; however, lhp1 mutants revealed a role for LHP1 in maintaining epigenetic silencing of FLC [4].
• Like LHP1, VRN1 functions in both flowering-time control and vernalization [4].

Biological context of TFL2

• The enhanced phenotype of the double mutant suggests that TFL2 acts in a developmental pathway distinct from TFL1 [5].
• TERMINAL FLOWER2 (TFL2) is the only homolog of heterochromatin protein1 (HP1) in the Arabidopsis genome [6].
• Instead, TFL2 acts as a repressor of genes related to plant development, i.e. flowering, floral organ identity, meiosis and seed maturation [6].
• In A. thaliana interphase nuclei, LHP1 was predominantly located outside the heterochromatic chromocenters [7].
• Furthermore, like the animal HP1beta and HP1gamma subtypes, LHP1 dissociates from chromosomes during mitosis [7].

Associations of TFL2 with chemical compounds

• However, the transcript level of the TU8/TFL2 gene after heat shock and jasmonate treatment did not change [8].

Regulatory relationships of TFL2

• Arabidopsis TERMINAL FLOWER 2 gene encodes a heterochromatin protein 1 homolog and represses both FLOWERING LOCUS T to regulate flowering time and several floral homeotic genes [9].

Other interactions of TFL2

• LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC [4].

Analytical, diagnostic and therapeutic context of TFL2

• Molecular cloning of TFL2 showed that it encodes a protein with homology to heterochromatin protein 1 (HP1) of animals and Swi6 of fission yeast [9].

References