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Gene Review

FZD6  -  frizzled class receptor 6

Homo sapiens

Synonyms: FZ-6, FZ6, Frizzled-6, Fz-6, HFZ6, ...
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High impact information on FZD6

  • We also detected Wnt-2b, Wnt-4, Wnt-5a, Wnt-5b, Frizzled 4, and Frizzled 6 in differentiated epithelial and mesenchymal cells of the small intestine and colon [1].
  • In Frizzled6 (Fz6)(-/-) mice, the global orientation of hair follicles is disrupted, leading to waves, whorls, and tufts, each comprising many hundreds of hairs [2].
  • Wnt-7a was exclusively expressed in the luminal epithelium, and Fz-6 and beta-catenin were expressed in both epithelium and stroma, without any apparent change during the cycle [3].
  • WNT receptor frizzled homolog 6 (FZD6) and prostaglandin-metabolizing enzyme hydroxyprostaglandin dehydrogenase were increased in SCC alone [4].
  • A subset of those genes (wnt2b, wnt5b, wnt10b, fzd6, fzd7) showed altered expression in hDFs exposed to DBP for 3 days. wnt and fzd gene expression was not altered before hDFs contacted the DBP within the collagen sponge [5].

Anatomical context of FZD6

  • Interestingly, the polarity of Fz6 localization with respect to the asymmetric position of the kinocilium is reversed between vestibular hair cells in the cristae of the semicircular canals and auditory hair cells in the organ of Corti [6].
  • In the inner ear, Fz3 and Fz6 proteins are localized to the lateral faces of sensory and supporting cells in all sensory epithelia in a pattern that correlates with the axis of planar polarity [6].

Other interactions of FZD6


Analytical, diagnostic and therapeutic context of FZD6


  1. Expression pattern of Wnt signaling components in the adult intestine. Gregorieff, A., Pinto, D., Begthel, H., Destrée, O., Kielman, M., Clevers, H. Gastroenterology (2005) [Pubmed]
  2. Order from disorder: Self-organization in mammalian hair patterning. Wang, Y., Badea, T., Nathans, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium. Tulac, S., Nayak, N.R., Kao, L.C., Van Waes, M., Huang, J., Lobo, S., Germeyer, A., Lessey, B.A., Taylor, R.N., Suchanek, E., Giudice, L.C. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  4. Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. Haider, A.S., Peters, S.B., Kaporis, H., Cardinale, I., Fei, J., Ott, J., Blumenberg, M., Bowcock, A.M., Krueger, J.G., Carucci, J.A. J. Invest. Dermatol. (2006) [Pubmed]
  5. Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Yates, K.E. Osteoarthr. Cartil. (2004) [Pubmed]
  6. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. Wang, Y., Guo, N., Nathans, J. J. Neurosci. (2006) [Pubmed]
  7. Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. Yang, L., Yamasaki, K., Shirakata, Y., Dai, X., Tokumaru, S., Yahata, Y., Tohyama, M., Hanakawa, Y., Sayama, K., Hashimoto, K. J. Dermatol. Sci. (2006) [Pubmed]
  8. Molecular cloning of human Frizzled-6. Tokuhara, M., Hirai, M., Atomi, Y., Terada, M., Katoh, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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