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Gene Review

Ndel1  -  nuclear distribution gene E-like homolog 1...

Mus musculus

Synonyms: 2600006O07Rik, MITAP1, NUDEL, Nuclear distribution protein nudE-like 1, Nudel, ...
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Disease relevance of Ndel1


High impact information on Ndel1

  • NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L) [1].
  • In addition, Ndel1(-/-) blastocysts failed to grow in culture and exhibited a cell proliferation defect in inner cell mass [2].
  • Although Ndel1(+/-) mice displayed no obvious phenotypes, further reduction of NDEL1 by making null/hypomorph compound heterozygotes (Ndel1(cko/-)) resulted in histological defects consistent with mild neuronal migration defects [2].
  • NUDEL was localized predominantly along microtubules of the manchette in elongated spermatids [3].
  • These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules [3].

Biological context of Ndel1


Anatomical context of Ndel1


  1. A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. Nguyen, M.D., Shu, T., Sanada, K., Larivière, R.C., Tseng, H.C., Park, S.K., Julien, J.P., Tsai, L.H. Nat. Cell Biol. (2004) [Pubmed]
  2. Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Sasaki, S., Mori, D., Toyo-oka, K., Chen, A., Garrett-Beal, L., Muramatsu, M., Miyagawa, S., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., Hirotsune, S. Mol. Cell. Biol. (2005) [Pubmed]
  3. Expression of NUDEL in manchette and its implication in spermatogenesis. Yamaguchi, N., Takanezawa, Y., Koizumi, H., Umezu-Goto, M., Aoki, J., Arai, H. FEBS Lett. (2004) [Pubmed]
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