Disease relevance of Ndel1

• Furthermore, variations in levels of NUDEL correlate with disease progression and NF defects in a mouse model of neurodegeneration [1].
• Knockdown of NUDEL by RNA interference (RNAi) in a neuroblastoma cell line, primary cortical neurons or post-natal mouse brain destabilizes NF-L and alters the homeostasis of NFs [1].

High impact information on Ndel1

• NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L) [1].
• In addition, Ndel1(-/-) blastocysts failed to grow in culture and exhibited a cell proliferation defect in inner cell mass [2].
• Although Ndel1(+/-) mice displayed no obvious phenotypes, further reduction of NDEL1 by making null/hypomorph compound heterozygotes (Ndel1(cko/-)) resulted in histological defects consistent with mild neuronal migration defects [2].
• NUDEL was localized predominantly along microtubules of the manchette in elongated spermatids [3].
• These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules [3].

Biological context of Ndel1

• Expression of NUDEL in manchette and its implication in spermatogenesis [3].

Anatomical context of Ndel1

• High levels of NUDEL were expressed in murine testis as well as brain [3].
• In maturing spermatids, NUDEL was observed only in the centrosomes, while mature testicular spermatozoa did not show any NUDEL expression [3].

References