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Gene Review

MSI1  -  histone-binding protein MSI1

Arabidopsis thaliana

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High impact information on MSI1

  • In Arabidopsis thaliana, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively [1].
  • Further more, msi1 mutant gametophytes initiate endosperm development in the absence of fertilization at a high penetrance [2].
  • In contrast with msi1, supernumerary nuclei in rbr1 female gametophytes originate mainly from the endosperm precursor lineage but do not express an endosperm fate marker [3].
  • As msi1 autonomous seeds mostly contain autonomous endosperm, our results indicate that the developing endosperm is sufficient to enhance cell proliferation and differentiation in the seed coat [3].
  • These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development [4].

Biological context of MSI1

  • We have cloned the MEDICIS gene and show that it encodes the Arabidopsis homologue of the yeast WD40 domain protein MULTICOPY SUPRESSOR OF IRA (MSI1) [5].
  • We report that single mutations in the gene MULTICOPY SUPPRESSOR OF IRA 1 (MSI1) are able to initiate parthenogenetic development of the embryo in Arabidopsis thaliana from eggs cells produced by meiosis [6].
  • MSI1 is needed to establish epigenetic H3K4 di-methylation and H3K9 acetylation marks in SOC1 chromatin [7].
  • Strong ectopic expression of AtMSI1 produced no visible altered phenotype, but reduction of AtMSI1 dramatically affected development [8].
  • Efficient formation of heterochromatin, but not methylation of centromeric DNA repeats, depends on AtMSI1 presence demonstrating a key role of AtMSI1 in maintenance of chromatin structure [8].

Other interactions of MSI1


  1. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. Endo, M., Ishikawa, Y., Osakabe, K., Nakayama, S., Kaya, H., Araki, T., Shibahara, K., Abe, K., Ichikawa, H., Valentine, L., Hohn, B., Toki, S. EMBO J. (2006) [Pubmed]
  2. Arabidopsis MSI1 is a component of the MEA/FIE Polycomb group complex and required for seed development. Köhler, C., Hennig, L., Bouveret, R., Gheyselinck, J., Grossniklaus, U., Gruissem, W. EMBO J. (2003) [Pubmed]
  3. The female gametophyte and the endosperm control cell proliferation and differentiation of the seed coat in Arabidopsis. Ingouff, M., Jullien, P.E., Berger, F. Plant Cell (2006) [Pubmed]
  4. Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development. Exner, V., Taranto, P., Sch??nrock, N., Gruissem, W., Hennig, L. Development (2006) [Pubmed]
  5. Identification of new members of Fertilisation Independent Seed Polycomb Group pathway involved in the control of seed development in Arabidopsis thaliana. Guitton, A.E., Page, D.R., Chambrier, P., Lionnet, C., Faure, J.E., Grossniklaus, U., Berger, F. Development (2004) [Pubmed]
  6. Loss of function of MULTICOPY SUPPRESSOR OF IRA 1 produces nonviable parthenogenetic embryos in Arabidopsis. Guitton, A.E., Berger, F. Curr. Biol. (2005) [Pubmed]
  7. Regulation of flowering time by Arabidopsis MSI1. Bouveret, R., Schönrock, N., Gruissem, W., Hennig, L. Development (2006) [Pubmed]
  8. Arabidopsis MSI1 is required for epigenetic maintenance of reproductive development. Hennig, L., Taranto, P., Walser, M., Schönrock, N., Gruissem, W. Development (2003) [Pubmed]
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