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Gene Review

HB5  -  homeobox-leucine zipper protein ATHB-5

Arabidopsis thaliana

Synonyms: ATHB-5, ATHB5, MNA5.4, MNA5_4, homeobox protein 5
 
 
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High impact information on ATHB5

  • ATHB5 is a member of the homeodomain-leucine zipper (HDZip) transcription factor gene family of Arabidopsis thaliana [1].
  • Moreover, analysis of ATHB5 gene expression during post-germinative growth in different ABA response mutants shows that ATHB5 gene activity is down-regulated in the abil-1, abi3-1 and abi5-1 mutant lines, but not in abi2-1 or abi4-1 [1].
  • In this report we show that increased expression levels of ATHB5 in transgenic Arabidopsis plants cause an enhanced sensitivity to the inhibitory effect of abscisic acid (ABA) on seed germination and seedling growth [1].
  • Consistent with this finding we have demonstrated the sequence-specific interaction of ATHB5 with a 9 bp pseudopalindromic DNA sequence, CAATNATTG, composed of two half-sites overlapping at a central position, by use of a PCR-assisted binding-site selection assay and competitive EMSA experiments [2].
  • These clones, Athb-5, Athb-6 and Athb-7, hybridized to transcripts that were relatively abundant in the leaf, but also present in other vegetative organs, as well as in the flower [3].
 

Biological context of ATHB5

 

Associations of ATHB5 with chemical compounds

  • Taken together, these data suggest that ATHB5 is a positive regulator of ABA-responsiveness, mediating the inhibitory effect of ABA on growth during seedling establishment [1].
 

Analytical, diagnostic and therapeutic context of ATHB5

  • Northern blot and promoter-GUS fusion analyses show that ATHB5 gene transcription is initiated rapidly after the onset of germination and localized primarily to the hypocotyl of germinating seedlings [1].

References

  1. The Arabidopsis thaliana homeobox gene ATHB5 is a potential regulator of abscisic acid responsiveness in developing seedlings. Johannesson, H., Wang, Y., Hanson, J., Engström, P. Plant Mol. Biol. (2003) [Pubmed]
  2. DNA-binding and dimerization preferences of Arabidopsis homeodomain-leucine zipper transcription factors in vitro. Johannesson, H., Wang, Y., Engström, P. Plant Mol. Biol. (2001) [Pubmed]
  3. Expression patterns of novel genes encoding homeodomain leucine-zipper proteins in Arabidopsis thaliana. Söderman, E., Mattsson, J., Svenson, M., Borkird, C., Engström, P. Plant Mol. Biol. (1994) [Pubmed]
 
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