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Gene Review

SESN2  -  sestrin 2

Homo sapiens

Synonyms: DKFZp761M0212, HI95, Hi95, SES2, SEST2, ...
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Disease relevance of SESN2


High impact information on SESN2

  • Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [1].
  • Overexpression of Hi95 full-length cDNA was found toxic for many types of cultured cells directly leading either to their apoptotic death or to sensitization to serum starvation and DNA damaging treatments [1].
  • In both groups there was a significant increase in scores in the Psychosexual Stimulation Scale of the SES (i.e. SES 2) following testosterone administration, but not with placebo [2].
  • Women in the treated group were less likely to have received further education than the controls, a factor that influences SES 1 and SES 2 scores [3].
  • Purified Hi95 (sestrin 2) protein supports adenosine triphosphate-dependent reduction of overoxidized PrxI in vitro, indicating that unlike AhpD, which is a disulfide reductase, sestrins are cysteine sulfinyl reductases [4].


  1. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Budanov, A.V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., Skaliter, R., Gudkov, A.V., Chumakov, P.M., Feinstein, E. Oncogene (2002) [Pubmed]
  2. The effects of exogenous testosterone on sexuality and mood of normal men. Anderson, R.A., Bancroft, J., Wu, F.C. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  3. Sexual function in women with epilepsy. Duncan, S., Blacklaw, J., Beastall, G.H., Brodie, M.J. Epilepsia (1997) [Pubmed]
  4. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Budanov, A.V., Sablina, A.A., Feinstein, E., Koonin, E.V., Chumakov, P.M. Science (2004) [Pubmed]
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