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Gene Review:

GSG2 - germ cell associated 2 (haspin)

Homo sapiens

Synonyms: Germ cell-specific gene 2 protein, H-haspin, Haploid germ cell-specific nuclear protein kinase, Serine/threonine-protein kinase haspin, haspin

Dai, J. et al., Dai, J. et al., Higgins, J.M., Nespoli, A. et al., Dai, J. et al.

Higgins,

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High impact information on GSG2

Haspin RNA interference causes misalignment of metaphase chromosomes, and overexpression delays progression through early mitosis [1].
In addition to its chromosomal association, haspin is found at the centrosomes and spindle during mitosis [1].
Importantly, depletion of haspin by RNA interference reveals that this kinase is required for H3 Thr 3 phosphorylation in mitotic cells [1].
Haspin (haploid germ cell-specific nuclear protein kinase) is reported to be a serine/threonine kinase that may play a role in cell-cycle cessation and differentiation of haploid germ cells [2].
Haspin is a protein kinase identified in mouse and human cells, and genes coding for haspin-like proteins are present in virtually all eukaryotic genomes sequenced so far [3].

Biological context of GSG2

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment [1].
Here we discuss possible mechanisms of haspin action and the function of histone phosphorylation in mitosis [4].
Haspin depletion disrupts cohesin binding and sister chromatid association in mitosis, preventing normal chromosome alignment and activating the spindle assembly checkpoint, leading to arrest in a prometaphase-like state [5].

Other interactions of GSG2

Regulation of mitotic chromosome cohesion by haspin and aurora B [5].

References

The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Dai, J., Sultan, S., Taylor, S.S., Higgins, J.M. Genes Dev. (2005) [Pubmed]
Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases. Higgins, J.M. Protein Sci. (2001) [Pubmed]
Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Nespoli, A., Vercillo, R., di Nola, L., Diani, L., Giannattasio, M., Plevani, P., Muzi-Falconi, M. Cell Cycle (2006) [Pubmed]
Haspin: a mitotic histone kinase required for metaphase chromosome alignment. Dai, J., Higgins, J.M. Cell Cycle (2005) [Pubmed]
Regulation of mitotic chromosome cohesion by haspin and aurora B. Dai, J., Sullivan, B.A., Higgins, J.M. Dev. Cell (2006) [Pubmed]

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