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Gene Review

Ralbp1  -  ralA binding protein 1

Rattus norvegicus

Synonyms: Cytocentrin, DNP-SG ATPase, Dinitrophenyl S-glutathione ATPase, Ral-interacting protein 1, RalA-binding protein 1, ...
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High impact information on Ralbp1


Biological context of Ralbp1

  • We interpret these results to suggest that cytocentrin is a cytoplasmic protein that becomes specifically activated or modified at the onset of mitosis so that it can affiliate with the mitotic poles where it may provide a link between the pericentriolar material and other components of the mitotic apparatus [3].
  • During metaphase, cytocentrin is located predominately at the mitotic poles, often appearing as an aggregate of small globular sub-components; it also associates with some polar microtubules [3].

Anatomical context of Ralbp1


Associations of Ralbp1 with chemical compounds


Other interactions of Ralbp1

  • To identify downstream targets that might mediate a Ral-specific function, we used a Saccharomyces cerevisiae-based interaction assay to clone a novel cDNA that encodes a Ral-binding protein (RalBP1) [1].
  • Identification of a 102 kDa protein (cytocentrin) immunologically related to keratin 19, which is a cytoplasmically derived component of the mitotic spindle pole [3].


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