The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Krt19  -  keratin 19, type I

Rattus norvegicus

Synonyms: CK-19, Cytokeratin-19, K19, Ka19, Keratin, type I cytoskeletal 19, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Krt1-19


High impact information on Krt1-19


Biological context of Krt1-19

  • The present results indicate that K18 and K19 gene expression is regulated at the transcriptional level [8].
  • As testicular differentiation progressed, K19 mRNA disappeared and, from 14.5 days of gestation on, fetal Sertoli cells expressed exclusively K18 mRNA [8].
  • The results reported here show first, that CKs are expressed before sexual differentiation in gonadal blastema in which no epithelial organization is observed, and second, that there is a CK 18/CK 19 shift in expression during morphogenesis of the testis which is not observed in the differentiating ovary [9].
  • The percent aneuploid cells and CK 19 staining were tested statistically and were shown to be negatively correlated [10].
  • In particular, cytokeratin 19 expression has been associated with the type II cell phenotype [11].

Anatomical context of Krt1-19

  • We used degenerate primers for the amino- and carboxyl-terminal ends of the rod domains of intermediate filament proteins in reverse transcriptase-PCR experiments to identify and clone cytokeratins 8 and 19 (K8 and K19) from cardiac muscle of the adult rat [12].
  • Northern blots showed that K8 has a 2.2-kb transcript and K19 has a 1.9-kb transcript in both adult cardiac and skeletal muscles [12].
  • The changes in the transcriptional activity of K19 and K18 genes, observed in male gonads, occur characteristically at the very beginning of testicular differentiation [8].
  • Cytokeratin 19 was also strongly expressed in all of the biliary epithelial cells, but in just some of the ductular hepatocytic cells, whereas only the latter cells were immunohistochemically positive for albumin and contained peroxisomes in their cytoplasm [13].
  • RT-PCR analysis for the stem cell marker Thy1 and the hepatocytic markers CK-18, albumin, CK-19, and AFP was performed in the different cell populations [14].

Associations of Krt1-19 with chemical compounds


Other interactions of Krt1-19


Analytical, diagnostic and therapeutic context of Krt1-19


  1. Liver carcinogenesis associated with feeding of ethionine in a choline-free diet: evidence against a role of oval cells in the emergence of hepatocellular carcinoma. Tarsetti, F., Lenzi, R., Salvi, R., Schuler, E., Rijhsinghani, K., Lenzen, R., Tavoloni, N. Hepatology (1993) [Pubmed]
  2. "Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan. Elmore, L.W., Sirica, A.E. Cancer Res. (1993) [Pubmed]
  3. Enzyme histochemical and immunohistochemical characterization of oval and parenchymal cells proliferating in livers of rats fed a choline-deficient/DL-ethionine-supplemented diet. Steinberg, P., Hacker, H.J., Dienes, H.P., Oesch, F., Bannasch, P. Carcinogenesis (1991) [Pubmed]
  4. Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages. Okumura, K., Nakamura, K., Hisatomi, Y., Nagano, K., Tanaka, Y., Terada, K., Sugiyama, T., Umeyama, K., Matsumoto, K., Yamamoto, T., Endo, F. Hepatology (2003) [Pubmed]
  5. Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. Mitaka, T., Sato, F., Mizuguchi, T., Yokono, T., Mochizuki, Y. Hepatology (1999) [Pubmed]
  6. Generation of hepatocytes from oval cell precursors in culture. Lázaro, C.A., Rhim, J.A., Yamada, Y., Fausto, N. Cancer Res. (1998) [Pubmed]
  7. Rearrangement of hepatocellular F-actin precedes the formation of rosette-like structures in parenchyma of cholestatic rat liver. Song, J.Y., Van Noorden, C.J., Frederiks, W.M. Hepatology (1998) [Pubmed]
  8. Switch in the expression of the K19/K18 keratin genes as a very early evidence of testicular differentiation in the rat. Fridmacher, V., Le Bert, M., Guillou, F., Magre, S. Mech. Dev. (1995) [Pubmed]
  9. Differential expression of acidic cytokeratins 18 and 19 during sexual differentiation of the rat gonad. Fridmacher, V., Locquet, O., Magre, S. Development (1992) [Pubmed]
  10. Correlation of DNA ploidy levels with altered cytokeratin patterns in rat bladder tumors. Reedy, E.A., Cottrell, J.R., Resau, J.H. Pathobiology (1991) [Pubmed]
  11. Regulation of cytokeratin expression in rat lung alveolar epithelial cells in vitro. Paine, R., Gaposchkin, D., Kelly, C., Wilcoxen, S.E. Am. J. Physiol. (1995) [Pubmed]
  12. Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. Ursitti, J.A., Lee, P.C., Resneck, W.G., McNally, M.M., Bowman, A.L., O'Neill, A., Stone, M.R., Bloch, R.J. J. Biol. Chem. (2004) [Pubmed]
  13. Ductular hepatocytes. Evidence for a bile ductular cell origin in furan-treated rats. Sirica, A.E., Gainey, T.W., Mumaw, V.R. Am. J. Pathol. (1994) [Pubmed]
  14. Liver-specific gene expression in mesenchymal stem cells is induced by liver cells. Lange, C., Bassler, P., Lioznov, M.V., Bruns, H., Kluth, D., Zander, A.R., Fiegel, H.C. World J. Gastroenterol. (2005) [Pubmed]
  15. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Bouwens, L., Wang, R.N., De Blay, E., Pipeleers, D.G., Klöppel, G. Diabetes (1994) [Pubmed]
  16. Hepatocytic differentiation of cultured rat pancreatic ductal epithelial cells after in vivo implantation. Chen, J.R., Tsao, M.S., Duguid, W.P. Am. J. Pathol. (1995) [Pubmed]
  17. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Nishikawa, Y., Doi, Y., Watanabe, H., Tokairin, T., Omori, Y., Su, M., Yoshioka, T., Enomoto, K. Am. J. Pathol. (2005) [Pubmed]
  18. In vitro differentiation of WB-F344 rat liver epithelial cells into the biliary lineage. Couchie, D., Holic, N., Chobert, M.N., Corlu, A., Laperche, Y. Differentiation (2002) [Pubmed]
  19. Morphology of liver repair following cholestatic liver injury: resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts. Ramm, G.A., Carr, S.C., Bridle, K.R., Li, L., Britton, R.S., Crawford, D.H., Vogler, C.A., Bacon, B.R., Tracy, T.F. Liver (2000) [Pubmed]
  20. Expression of the Wnt gene family during late nephrogenesis and complete ureteral obstruction. Nguyen, H.T., Thomson, A.A., Kogan, B.A., Baskin, L.S., Cunha, G.R. Lab. Invest. (1999) [Pubmed]
  21. Phenotype and differentiation patterns of the oval cell lines OC/CDE 6 and OC/CDE 22 derived from the livers of carcinogen-treated rats. Radaeva, S., Steinberg, P. Cancer Res. (1995) [Pubmed]
  22. Exposure of primary rat hepatocytes in long-term DMSO culture to selected transition metals induces hepatocyte proliferation and formation of duct-like structures. Cable, E.E., Isom, H.C. Hepatology (1997) [Pubmed]
  23. Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation into adult rat liver. Dabeva, M.D., Petkov, P.M., Sandhu, J., Oren, R., Laconi, E., Hurston, E., Shafritz, D.A. Am. J. Pathol. (2000) [Pubmed]
  24. Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells. Vroman, B., LaRusso, N.F. Lab. Invest. (1996) [Pubmed]
WikiGenes - Universities